舍曲林联合齐拉西酮胶囊治疗难治性强迫症的临床研究

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1、舍曲林联合齐拉西酮胶囊治疗难治性强迫症的临床研究王晓洪(泸州市精神卫生中心四川泸州646000)【摘要】目的：探讨舍曲林联合齐拉西酮胶囊治疗难治性强迫症的临床疗效。方法:筛选2014年1月至2015年1月我院收治的难治性强迫症患者76例，作为研究对象。采用随机数表法将其分为观察组与对照组，每组患者38例，其中对照组患者单纯应用舍曲林治疗，观察组患者在舍曲林治疗的基础上加用齐拉西酮胶囊治疗，比较两组患者治疗后临床症状改善情况以及治疗总有效率。结果:两组患者治疗前Y-BOCS评分分比较无显著无显著差异，治疗6周

2、后均有所改善，但观察组患者改善效果更为显著，与对照组比较存在显著差异(P<0.05)；观察组患者治疗总有效率为92.11%,明显高于对照组治疗总有效率78.95%,P<0.05,具有统计学意义；两组患者治疗后TESS评分比较均无显著差异(P>0.05)o结论:采用舍曲林联合齐拉西酮胶囊治疗难治性强迫症疗效确切，较单纯用药具有更高的症状改善效果。【关键词】舍曲林；齐拉西酮；难治性强迫症；临床疗效【中图分类号】R97【文献标识码】A【文章编号】2095-1752(2016)03-0035-02

3、Theclinicalresearchofsertralinecombinedwithziprasidonecapsuleinthetreatmentofrefractoryobsessive-compulsivedisorderWangXiaohong,TheMentaiHealthCenterofLuzhou,SichuanLuzhou646000,China[Abstract]ObjectiveTodiscusstheclinicaleffectofsertralinecombinedwithzipr

4、asidonecapsuleinthetreatmentofrefractoryobsessive-compulsivedisorder.Methods76caseswithrefractoryobsessive-compulsivedisorder,whichadmittedinourhospitalduringJanuary2014–January2015,wereselectedastheresearchobjectanddividedintotheobservationgroupandt

5、hecontrolgroupeachgroupof38cases,accordingtorandomnumbertablemethod・Thecontrolgroupwasgivenpuresertralinetreatmentandtheobservationgroupwasgivenziprasidonecapsuletreatmentonthebasisofsertralinetreatment.Clinicalsymptomsimprovedaftertreatmentandthetotaleffe

6、ctiverateofthetwogroupswerecompared.ResultsY・BOCSscorebeforetreatmentinbothgroupswasnosign讦icantdifferenee.Aftertreatment6weeks,therewassomeimprovementofthetwogroups,whiletheimprovementoftheobservationgroupwasmoresignificant,significantdifferencescomparedw

7、ithcontrolgroup(P<0.05).Thetotaleffectiverateoftheobservationgroupwassign讦icantlyhigherthanthatofthecontrolgroup78.95%,thediffereneewassignificantstatisticallysignificant(P<0.05).TESSscoreaftertreatmentofbothgroupswerenosign讦icantdifferenee(P>0.05

8、).ConclusionThesertralinecombinedwithziprasidonecapsuleinthetreatmentofrefractoryobsessive-compulsivedisorderhasexactcurativeeffect,comparedwiththesimplemedicationhashighersymptomimprovementeffect,andtheappli