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1、对比丙硫氧喘噪与甲號咪卩坐治疗Graves病对肝功能的影响江苏省原子医学研究所附属江原医院214063【摘要】目的对比丙硫氧卩密噪与甲毓咪哇治疗Graves病对肝功能的影响及疗效,为临床治疗提供参考。方法选取2014年5月到2015年2月在我院诊断为Graves病患者86例为观察对象，选取白细胞3.5-4.5×109/L,中性粒细胞1.5-2.0×109/L予丙硫氧卩密噪治疗的患者43例，定为A组。选取同期白细胞>4.5×109/L,中性粒细胞>2.0×10
2、9/L予甲蔬咪“坐治疗的患者43例，为B组，要求与A组年龄、性别、病情严重程度相匹配。治疗6月对比两组肝功能指标。结果A组患者出现肝功能损害13例(30.23%),B组4例(9.3%)(P<0.05)oA组肝功能损害发生时间为1.27月，B组患者0.625月。A组治疗后主要是转氨酶上升，占84.61%；B组主要是胆红素上升，占75%,两组患者治疗均有较好疗效。结论丙硫氧卩密噪与甲铳咪“坐治疗Graves病均有疗效，丙硫氧U密噪对肝功能的损害机率更大，甲疏咪卩坐引起肝功能损害的时间更早，都值得引起重视，服药期间需
3、定期检查肝功能，及时给予保肝治疗。【关键词】丙硫氧卩密噪；甲毓咪哇；Graves病；肝功能ComparisonoftheefficacyofpropylthiouracilandmethimazoletreatmentofGravesdiseaseonliverfunction[AbstractJObjectiveTheimpactonliverfunctionandcurativeeffectofpropylthiouracilandmethimazoletreatmentofGravesdisease,topro
4、viderefereneeforclinicaltreatment-MethodsFromMay2014toFebruary2015,86patientswithGravesdiseaseweretreatedinourhospitalfromto.Selectionofwhitebloodcell3.5~4.5×109/L,neutrophil1.5~2.0×109/Lgivepropylthiouraciltherapyforpatientswith43cases,asgroupA,Sel
5、ectthesameperiodbloodwhitecells>4.5×109/L,neutrophilswerehigherthan>2.0×109/L,givingmethimazoletreatmentinpatientswithGravesdisease43,asgroupB,requirementsandagroupofpatientswithage,gender,severityofphasematching.Liverfunctionindexofthetwogrou
6、pswerecomparedinsixmonths.Results13cases（30.23%）ofliverfunctiondamageingroupA,4cases（9.3%）ingroupB.ThepatientswithliverfunctiondamageingroupAwerewithin1.27months,within0.625monthsofgroupB.Aftertreatment,groupAwasincreasedby84.61%groupB,thebilirubinincreased,acc
7、ountingfor75%.TwogroupsofpatientsweretreatedwithbettercurativeeffectConclusionPropylthiouracilandmethimazoletreatmentofGravesdiseasehasthecurativeeffectandpropylthiouracilonliverfunctiondamagemorelikely,methimazoleinducedliverfunctionimpairmentofanearliertime,n
8、eedtobeworthyofattentionandmedicationduringroutineliverfunctiontest,timelytreatmentofliver.[Keywords]propylthiouracil；methimazole；Gravesdisease；liverfunction甲状腺功能亢进症（简称甲亢），是
