欢迎来到天天文库
浏览记录
ID:27834645
大小:57.00 KB
页数:8页
时间:2018-12-06
《理筋手法对外周炎性痛大鼠局部镇痛作用及其机制的实验研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、理筋手法对外周炎性痛大鼠局部镇痛作用及其机制的实验研究【摘要】目的:探讨理筋手法对炎症性疼痛大鼠的局部镇痛作用及其机制。方法:将24只SPF级健康雌性SD大鼠随机分为空白组、模型组、手法组,每组8只。除空白组外,其他2组在大鼠足底皮下注射0.1mL弗氏完全佐剂,建立佐剂性外周炎性痛模型,通过在疼痛局部施以理筋手法,观察手法对大鼠炎症反应、疼痛阈值及局部腺甘含量的影响。结果:造模后,大鼠出现致炎侧足跛行、舔爪、红、肿及热痛敏等反应。造模局部组织可见炎性细胞浸润,肌纤维的萎缩等。手法能抑制弗氏佐剂导致的大鼠缩足、舔爪等自发痛行为,提高炎性痛大鼠的疼痛阈
2、值(P<0.05);且能提高大鼠足底病灶局部腺昔含量,手法组局部腺背含量与空白组、模型组比较,差异有统计学意义(P<0.05)o结论:理筋手法局部镇痛效果显著,其局部镇痛作用可能通过局部腺昔释放而起作用。【关键词】理筋手法;完全弗氏佐剂;炎性痛;镇痛作用;腺昔;大鼠ExperimentalStudyontheLocalAnalgesicEffectofTendon-SoothingManipulationonRatswithPeripheryInflamniQtoryPainandItsMechanismZHAOLi-jing,LIPei,ZHAN
3、GZhong-bo,CHENYan-wei,SHIPeng-bo,BAZheng[ABSTRACT】0bjective:Toinvestigatethelocalanalgesiceffectoftendon-soothingmanipulationonratswithperipheryinflammatorypainanditsmechanism・Methods:TwentyfourhealthyfemaleSDratswererandomlydividedintoablankgroup,amodelgroupandamanipulationgr
4、oup,with8ratsineachgroup・Excepttheblankgroup,theothertwogroupsweregivensubcutaneousinjectionof0.1mLFreuncTsadjuvantintheplantartoestablishmodelswithadjuvantperipheralinflammatorypain.Tendon-soothingmanipulationwasusedtoobserveitseffectontheirinflammatoryreaction,painthresholda
5、ndlocalcontentofadenosine・ResuIts:Aftermodeling,ratshadthefollowingreactions:claudicationontheinflammatoryside,1ickingclaws,red,swol1enandheathyperalgesia.Tnflammatorycel1infiltrationandatrophyofmusclefiberswereseeninthelocaltissueformodeling.ManipulationcouldinhibitFreund'sad
6、juvantcausedspontaneouspainbehaviorssuchascurlinguplegsandlickingclawsandlifttheirpainthreshold(P<0.05)・Italsocouldimprovethecontentofadenosineinratsplantarlesions.Thedifferenceofthecontentofadenosinebetweenthemanipulationgroup,theblankgroupandthemodelgroupwasstatisticallysign
7、ificant(P〈0.05)・Conclusion:Thetendon-soothingmanipulationhasanobviouslocalanalgesia,whosefunctionmaybeplayedbylocallyreleasedadenosine.[Keywords]tendon-soothingmanipulation;completeFreund,sadjuvant;inflanrnidtorypain;analgesiceffect;adenosine;rats理筋手法是中医骨伤科治疗筋伤的常用方法,具有活血止痛、消散瘀
8、肿、理顺筋脉、解除筋肉痉挛、使筋岀槽、骨错缝得以纠止至止常的作用[1]。其在缓解疼痛方面疗效突出,但是长期以来关于理筋手法
此文档下载收益归作者所有