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时间:2018-12-06
《癫痫患者骨密度改变的性别差异及相关影响因素分析》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、癫痫患者骨密度改变的性别差异及相关影响因素分析[摘要]目的评价癫痫患者骨密度及骨代谢相关指标的改变,探讨癫痫患者骨代谢界常的性别差界及其相关影响因素,旨在为临床治疗提供依据。方法入选110例女性癫痫患者及96例男性癫痫患者进行观察,并设立健康女性45例及健康男性40例作对照。收集癫痫患者相关临床资料,対各组分别测定骨密度及骨代谢相关生化指标,并进行统计学分析。结果癫痫组骨密度异常比例及甲状旁腺素均较健康对照组升高,女性癫痫组骨密度显常比例高于男性癫痫组(均P<0.05)o影响因素分析中,年龄、药程、
2、药物数量、癫痫发作对骨密度均有负面作用(均P<0.05),年龄对女性患者骨密度影响更加明显,病程、药物种类仅对女性患者骨密度影响显著。多因素回归分析显示,年龄、病程、药物数量是女性患者骨质异常的危险因素,而药程、药物数量是男性患者骨质异常的危险因素(均P<0.05)o结论癫痫病及抗癫痫药(AEDs)均影响患者骨密度,并可继发甲状旁腺功能亢进。女性患者骨密度异常比例高于男性患者,且骨质异常的影响因素更多,在临床治疗中应给予更多的关注。[关键词]癫痫;骨密度;抗癫痫药物;性别差异[中图分类号]R742.
3、1[文献标识码]B[文章编号]1673-9701(2014)33-0009-04[Abstract]ObjectiveToevaluatethebonemineraldensity(BMD)andrelativebiochemicalindicatorsofbonemetabolisminpatientswithepilepsy,toexploreinfluencingfactorsandgenderdifferencesofabnormalbonemetabolisminpatientswithe
4、pilepsy,toprovidereferencedataforclinicaltreatment.MethodsAtotalof110femalewithepi1epsyand96malewithepilepsywereobserved,comparedto45healthywomenand40healthymenascontrolgroups.Clinicaldataofpatientswithepilepsywerecollected,BMDandbiochemicalindicatorsw
5、eremeasuredintheexperimentalgroupsandthecontrolgroupsrespectively.Theallofthedatawereanalyzcdbystatisticalmethods.ResultsIncideneeoflowBMDandtheparathyroidhormoneincreasedinthepatientsgroupscomparedtothehealthygroups,incidenceoflowBMDinfemalepatientsgr
6、oupwashigherthanmalepatientsgroup(P<0-05).Analysisofinfluencingfactors,age>timeontreatment>numberofantiepilepticdrugs(AEDs)andseizuresal1haveadverseimpactonBMD(P<0.05).TheeffectofageonBMDwasmorevisibleinfemalepatientsgroup・Significanteffectofcourseandt
7、ypeofAEDsonBMDwasonlyfoundinfemalepatientsgroup.Mutivariateregressionanalysisshowed,age>course、numberofAEDswereriskfactorstofemalepatientswithabnormalbonemetabolism,whi1etimeontreatment、numberofAEDswereriskfactorstomalepatients(P<0.05)・ConclusionEpilep
8、syandAEDsbothhavenegativeimpactonBMD,andmayleadtosecondaryhj^perparathyroidism.IncideneeoflowBMDinfemalepatientsgroupwashigherthanmalepatientsgroup,andmoreinfluencingfactorscontributetoabnormalBMDinfemalepatientsthanmalepatients,somorea
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