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1、瘦素瘦素受体相关信号通路与肿瘤的研究进展1.南华大学附属郴州医院湖南郴州423000；2.南华大学附属南华医院湖南衡阳421000摘要：流行病学调查显示肥胖是多种肿瘤的形成的危险因素。肥胖，被认为是一种轻微的炎症反应过程，其特征性表现是脂肪组织高水平分泌与肿瘤发牛发展相关的细胞因子如：瘦素。瘦素是一种主要由白色脂肪合成、分泌的多肽类激素,在肥胖相关肿瘤中有促炎症反应、促血管牛成、扩散、迁移、凋亡等的作用。研究表明瘦素受体在多种类型肿瘤中过度表达，且与肿瘤血管牛成、肿瘤细胞凋亡、炎症反应、促有丝分裂活性具有相关
2、性。瘦素/瘦素受体主要是通过经典的信号通路Janus激酶2/信号转导和转录激活因了3(JanusKinas2/SignalTransducersandActivatorsofTranscription3,JAK2/STAT3),促分裂素原活化蛋白激酶/细胞外调节蛋白激酶1/2(Mitogenactivatedproteinkinase/Extracellularregulatedkinase1and2,MAPK/ERK1/2),磷脂酰肌醇3激酶/蛋白激酶B(Phosphoinositide3-kinase/P
3、roteinkinaseB,PI3K/AKT)和非经典信号通路维持机体食物摄取、能量平衡、脂肪代谢、免疫反应、内分泌系统的稳定，且能在肿瘤发生、发展过程中起作用。但是，瘦素促进肿瘤发牛发展的的机制善不完全清楚。木文从瘦素通过经典的JAK2/STAT3,MAPK/ERK1/2,PI3K/AKT对肿瘤影响的研究做一综述。关键词：瘦素；瘦素受体;JAK2/STAT3信号通路；MAPK/ERK1/2信号通路；PI3K/AKT信号通路；肿瘤Leptin/LeptinReceptorSignalingPathwayres
4、earchprogressofeffectsonTumorsAbstactEpidemiologicstudieshavesuggestedobesitymayasahighriskfactorinvariouscancers.Obesityisredardedasamildinflammatorycondition,itscharacteristicishighlevelsofcytokinesfromadiposetissuesecretoryrelatedtocancersdevelopmentsuch
5、as：Leptin.Leptin,mainlysecretedbyadiposetissue,peptidehormonesecretion,areinvolvedinthsesbiologicalprocessespro-inflammatory,pro-angiogenic，proliferation,migration,anti-apoptosisinobesity-relatedcancers.SupportingevideneeoverexpressionofLeptinreceptor(Ob-R)
6、invariouscancer,andinvolvedinangiogenic,apoptosis,inflammatoryresponses,mitogenicactivity.Leptin/LeptinReceptorisresponsibleforseveralcanonicalsignalingpathwayssignaltransductionthroughtheactivationofJanus-activatedkinase2(JAK2)/signaltransducersandactivati
7、orsoftrainscription3(STAT3),themitogen-acctivatedproteinkinase(MAPK)/extracellularsignal-regulatedkinase(ERK),phosphatidylinositol3-kinase(PI3K)/proteinkinaseB(AKT)andnon-canonicalsignalingpathways.Leptin-inducedsignalsisessentialtoitsbiologicaleffectsonfoo
8、dintake,energybalanee,adiposity,immuneandendocrinesystems,aswellasoncogenesis.Currently,themoleculesmechanismsthatundeliethiscormectionbetweenleptinandvariouscancers.Thisreviewaddressesthecurrentlevelo
