凋亡相关因子xaf—1和xiap的表达及与膀胱癌复发的相关性研究

《凋亡相关因子xaf—1和xiap的表达及与膀胱癌复发的相关性研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、凋tt联E?XAF—1和XIAP臓达R与膀胱（韻S挪究2018-03-2910:29:58中国现代医生2018年6期张庆德蔡学辉潘》姜文元柳》吴永进王健［摘耍］鬥的探討凋亡抑制蛋白XIAP和XIAP相关因子1(XAF-1)的表达及与膀胱癌复发的相关性《方法以第-次复发的20例膀胱癌患者(复发组)和K对应的20例初发的膀胱癌患者(初发组)为研宂对象，对照组力20例复发的膀胱癌患者的正常膀胱组织。采用免疫组化方法(SABC)检测XIAP和XAF-1在初发组、复发组、对照组屮的表达水平，分析与膀胱癌进展和复发的关系，同吋分析XIAP和XAF-1与肿瘤数H、是否肌足浸润、临

2、床分期及恶性程度分级的相关性。结果在初发组与复发组屮XIAP的表达强度与临床分期、恶性程度分级呈正相关(P<0.05);即XIAP在不同的临床分期、恶性程度分级的表达强度不同，分期越高，表达强度越强。在初发组与复发组中XAF-1的表达强度与临床分期、恶性程度分级呈负相关(P<0.05)，即XAF-1在不同的临床分期、恶性程度分级的表达强度不同，分期越商，表达强度越低。XIAP,XAF-1的表达强度在肿瘤数目、足否肌足没润均无明显相关性(P>0.05)。对照组、初发组、笈发组XIAP指标与XAF-1指标相关(P<0.01)，呈负相关，XIAP指标越高，XAF-1指标相

3、对低。结论XIAP异常高表达和XAF-1异常低表达可能在膀胱癌发病和病惜进展中起重要作用，为膀胱癌的治疗和判断预后提供了新思路。［关键词］XIAP:XAF-1；膀胱癌;复发［屮图分类号］R737.14［文献标识码］A［文章编号］1673-9701(2018)06-0024-04［Abstract］ObjectiveToinvestigatetheexpressionofapoptosisrelatedfactorsXAF-1andXIAPandtheircorrelationwithbladdercancerrecurrence.Methods20patientsw

4、ithrecurrentbladdercancerinthefirsttime(recurrentgroup)and20patientswithprimarybladdercancer(primarygroup)wereselectedasthestudysubjects.Thecontrolgroupconsistedof20normalbladdertissuesofpatientswithrecurrentbladdercancer.TheexpressionlevelsofXIAPandXAF-1inprimary,recurrentandcontrolgr

5、oupsweredetectedbyimmunohistochemistry(SABC),andtheirrelationshipwithbladdercancerprogressionandrelapsewasanalyzed.Atthesametime,thecorrelationbetweenXIAP,XAF-1andthenumberoftumors,whethermyometrialinvasion，clinicalstageandgradeofmalignancywasanalyzed.ResultsTheexpressionlevelofXIAPwas

6、positivelycorrelatedwithclinicalstageandmalignantgradeintheprimarygroupandtherecurrentgroup(P<0.05),thatwas,theexpressionlevelofXIAPindifferentclinicalstagesandmalignantgradewasdifferent，andthehigherthestaging，thestrongertheexpressionintensity.TheexpressionintensityofXAF-1inprimarygrou

7、pandrecurrentgroupwasnegativelycorrelatedwithclinicalstageandmalignantgrade(P<0.05),thatwas,theexpressionlevelofXAF-1indifferentclinicalstagesandmalignantgradewasdifferent，andthehigherthestaging,theweakertheexpressionintensity.TheexpressionintensityofXIAPandXAF-1wasnotsignificantlyco