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1、rTMS辅助改善抑郁发作患者临床症状及记忆障碍对比研究(1.长春市第穴医院吉林长春130052;2.K:春吉柴医院吉林松春130052)【摘要】目的:探讨rTMS辅助改善抑郁发作患者临床症状及记忆障碍影响。方法:选取抑郁发作患者60例,常规药物治疗,随机分成药物治疗组(对照组)和辅助rTMS治疗组(rTMS组)。rTMS组患者采用左侧前额叶治疗(10Hz、100%MT刺激总量750/次),每H—次;治疗前与治疗2周后分别进行SCL-90及MQ检查。结果:两组在治疗前SCL-90总分、记忆商数及各因子分相比无差异性(p〉0.05)。治疗后2周,rTMS组SCL-90总分下降明显,与对照组相比有差
2、异性(p<0.03),两组各因子分rTMS组比对照组下降明显,躯体化、强迫、敌对、精神病性、其他因素无差别性(p〉0.05),人际、抑郁、焦虑、恐怖、偏执有差别性(分别为p<0.01,p<0.03,p<0.05);两组的记忆商数均有不同程度的提高,rTMS组高于对照组,但两组相比无差别性(p〉0.05),记忆商数各因子分,指向记忆、指向记忆反应时、联想学习、无意义图形再认、人像特点联系记忆相比无差别性(p〉0.05),图像自由回忆及其反应时两组相比有差别性(p<0.03,p<0.01)o结论:rTMS在改善抑郁症临床症状方面具有提效和增效的作用,可以提高一定的记忆力水平,尤其是改善图像自由回忆
3、方面效果显著。【关键词】rTMS;抑郁发作;记忆商数【中图分类号】R544.1【文献标识码】A【文章编号】1004-6194(2015)02-0282-02[Abstract]Objective:ToexploretheinfluenceofmemorydeficitsandclinicalsymptomswhenweusedrTMStotreatthepatientsofdepressivedisorder.Methods:Weselected60depressionpatientswithroutinedrugtodivideintotwogroups:simpledrugtreatmen
4、tgroup(controlgroup)andauxiliaryrTMStreatmentgroup(rTMSgroup).ThepatientsofrTMSgroupwouldadoptleftprefrontaltreatmentonceaday(10Hz,100%MTstimulatetotal750/time),thancheckSCL-90andMQtestsbeforeandaftertwoweeks.Results:Therewerenosignificantdifference(p>O.O5)beforetreatmentintwogroups.Aftertwoweeks
5、,thetotalscoreofSCL-90decreasedsignificantlyandshoweddifferencewiththecontrolgroup(P<0.03)..Alloffactorscoreswentdown.Therewerenosignificantdifferencesaboutsomatization,compulsion,hostility,psychoticandothers(p>0.05),butsignificantdifferenceaboutinterpersonalrelationshipp,depression,anxiety,ph
6、obia,paranoid(P<0.01,P<0.03,P<0.05)betweencontrolgroupandrTMSgroup.TwogroupsofMQimprovedinvaryingdegrees,rTMSgroupwashigherthanthecontrolgroup,butTherewerenosignificantdifference(p>0.05).WefoundnosignificantdifferenceaboutsomefactorsbetweenrTMSgroupandcontrolgroup(p>0.05),includingpoi
7、ntmemery,reactiontimeofpointmemory,associativelearning,meaninglesspicturerecognition,portraitfeaturesmemory.ThereweresignificantdifferenceofpicturesrecallandtimebetweenrTMSgroupandcontrolgroup(p<0.03,