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页数:35页
时间:2018-12-02
《塑化剂与儿童健康》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、塑化劑與兒童健康台大醫院小兒部李秉穎《國衛院長達10年追蹤調查指出》台灣兒童塑化劑暴露量歐美數倍2011.5.28自由時報若由尿中DEHP代謝物殘留量回推每日暴露量,二至三歲幼兒每天每公斤體重的暴露量為七到二十微克(百萬分之一公克),高暴露量組已達美國最大容許量標準的每天每公斤體重二十微克,但低於歐盟標準的五十微克。在致癌風險方面,國衛院院長伍焜玉指出,DEHP人體研究資料太少,依此對人類致癌風險無法評估,但他相信大量長期攝取,應會致癌。研究人員認為,此異常現象不排除與加工食品中遭添加DEHP有關。EstimateddailyintakeofphthalateTaiwan,N=189,NH
2、RI,2011μg/kg/day(幾何平均、範圍)孕婦2-3歲5-6歲歐盟上限DEHP2.38.110.950(2-8)(7-20)(6-10)DiBP0.261.280.9110(0.2-1)(0.7-1)(1-2)BBP0.020.170.17500(0.01-0.08)(0.09-0.3)(0.1-0.2)DiNP2.6515.318.2150(2-9)(10-30)(10-20)LinS.Chemosphere2011;82:947.PhthalateexposureincentralTaiwanN=189,NHRI,2011Totalurinaryphthalatemetabol
3、iteconcentration(geometricmean,μgL-1)wasfoundtobehigherin2-years-olds(399)and5-years-olds(334)thanpregnantwomen(205).AlthoughestimateddailyintakevaluesarebelowtolerabledailyintakeaccordingtoCSTEE1998,andEFSA.MiBPandMnBPlevelsinmaternalurinewerehigherthanthosereportedformotherswhogavebirthtonewborn
4、swithshorterano-genitaldistances,indicatingariskpotentialofanti-androgeniceffectsforthisgroup.LinS.Chemosphere2011;82:947.尿液MEHP濃度台灣vs.17個國外研究LinS.Chemosphere2011;82:947.KavlockR.ReprodToxicol2006;22:291.台灣孕婦台灣兒童尿液phthalate濃度台灣vs.美國LinS.Chemosphere2011;82:947.SathyanarayanaS.Pediatrics2008;121;e26
5、0.Phthalatemetabolites尿液濃度(幾何平均,μg/L)DecreaseinanogenitaldistanceamongmaleinfantswithprenatalphthalateexposureN=134,USA,2005Anogenitalindex(AGI):distance/weightSwanSH.EnvironHealthPerspect2005;113(8):1056.SourceofexposureforchildrenFoodandfoodpackaging–plasticwrap(DEHP),foodprocessingusingPVCglove
6、sPVC-containingplasticproducts–plastictoys,bathbooks,teethers…Phthalate-containingmedicaldevicesforthehospitalizedpopulationDietary(breastmilk,infantformula,cow’smilk)-throughpersonalcareproductandbackgroundphathalateinindoorairanddust嬰兒用品常含有phthalateN=163,2000-2005,美國SathyanarayanaS.Pediatrics200
7、8;121;e260.81%infants:>7phthalatemetabolitesabovethelimitofdetection.嬰兒用品常含有phthalateN=163,2000-2005,美國SathyanarayanaS.Pediatrics2008;121;e260.嬰兒用品用愈多,尿液phthalate濃度愈高N=163,2000-2005,美國SathyanarayanaS.Pediatrics20
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