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1、-2伤后有氧运动使免疫抑制复合皮肤创伤小鼠脾脏系数、胸腺系数均得到适量提升，脾脏T淋巴细胞和B淋巴细胞增殖能力得到显著上升，从而增强免疫抑制小鼠脾脏介导的免疫功能。3伤后有氧运动对免疫抑制复合皮肤创伤小鼠创面VEGF的表达有明显影响。综上，伤后有氧运动增强创伤小鼠伤后免疫应激能力，提升小鼠皮肤创面愈合速率。关键词：有氧运动；创面愈合；免疫；VEGFIII----ABSTRACTObjectiveTherearemanycellsinvolvedinthewoundsurfacehealing,whichisa
2、verycomplexandorderlyprocess.Whileintheprocessofcellproliferation,manykindsoffactorsandgroundsubstancesecrete.Therearemanyclinicalresearchabouttheeffectofimmunocyteandgrowthfactoronwoundsurfacehealing,mainlyadoptingthemedicinalintervention.Thedomesticisstil
3、llessdetailedreportsaboutaerobaticexerciseinterference.Itisageneralconsensusthatlong-termappropriateaerobaticexercisecanstrengthenthebodyandimprovecardiopulmonaryfunction.Thisstudyattemptstoinvestigatetheeffectofspleen-mediatedimmunefunctionandexpressionofV
4、ascularEndothelialGrowthFactor(VEGF）onwoundsurfacehealingundertheconditionofaerobaticexerciseinterventiononmiceafterinjury,revealtheeffectofaerobaticexerciseinterventiononwoundsurfacehealingandprovidelaboratoryreferenceforclinicalapplicationofaerobicexercis
5、etherapy.MethodTheresearchselectedseventySPFgradeeight-week-oldhealthyKunmingmalemiceasexperimentalobject.AllofthemicearerandomlydividedintoA,B,C,Dgroups.GroupA:wound+exercise;GroupB:wound+quiet;GroupC:immunologicalsuppression+wound+exercise;GroupD:immunolo
6、gicalsuppression+wound+quiet.Micearecommonlybreededtoacclimatetheenvironmentfor3days,CandDgroupabdominalcavityinjectionofhydrocortisonecontinuousinjectionof0.5mg/day,7daysduetoimmunosuppressionmodel.A,B,C,Dgroupturnwheelfatiguetestersportsadaptto3days,refer
7、edtothemethodofFuXiao-bingetctomakewoundsurfacemodelandthenpractisedtheaerobaticexerciseinterferenceaccordingtoexperimentalprogramrespectively.ThemethodofaerobaticexerciseinterferencereferedtoK.ToddKeylock’smethod,whoadoptedRotorcageexercise.With15r/min,20m
8、in/times/day,aerobicexerciseinterventionfor10days.TracingIV----thewoundsurfacewithtransparentfilm,recordingwoundarea,calculatingthewoundhealingvelocitywithimageanalysissoftwareinthefirstday,thirdday,si
