唐氏筛查在高龄孕妇中应用价值的探讨

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1、唐氏筛查在高龄孕妇中应用价值的探讨徐群1孙洪丽2(1昆明市宜良县第一人民医院妇产科云南昆明652100)(2昆明市妇幼保健院围产保健中心云南昆明650028)【摘要】目的探讨高龄孕妇(≥35岁)进行唐氐筛查的价值及在产前诊断中的作用。方法对7854例15-20周的孕妇进行唐氏血清甲胎蛋白(AFP)和游离雌三醇(uE3)游离人绒毛膜促性腺激素(β-HCG)三联法检测，并随访所有唐氐筛查孕妇的妊娠结局。结果唐氐筛查孕妇7854例，检山高风险孕妇474例，筛查阳性率为6.04%；其中高龄孕妇有520例，高风险高龄

2、孕妇163例，筛查阳性率为31.34%,高龄孕妇筛查阳性率明显高于适龄孕妇(P<0.05)。随访妊娠结局:诊断唐氏儿8例，其中高龄孕妇5例，(唐氏筛查均为高风险)。结论高龄孕期行唐氏筛查，据筛查结果行产前诊断，可提高人口素质，减少出生缺陷儿发生率。【关键词】唐氏筛查高龄孕妇探讨【中图分类号】R173【文献标识码】A【文章编号】2095-1752(2013)27-0147-02InvestigationoftheapplicationvalueofDown’ssyndromescreeninginhigh-agedpr

3、imiparaXuQun1SunHongli21KunmingTheFirstPeople’sHospitalofYiliangCounty,Kunming,Yunnan6521002KunmingMaternalandChildHealthHospital,PerinatalHealthCareCenterKunming,Yunnan650028【Abstract】Objective:ToinvestigatethevalueofDown’ssyndromescreeninginthehigh-agedpri

4、mipara(≥35yearsold)andtheprenataldiagnosiseffectbasedonthat.Methods:totest7854womenof15-20weekspregnancywithDown’sserumalpha-fetoprotein(AFP)andfreefemalethreealcohol(uE3)freehumanchorionicgonadotropin(β-HCG)tripleassay,followingupallthepregnantwomen

5、whohadbeentestedandcollectingtheresultsofthat.Results:Inthese7854cases,474pregnantwomenhadbeendetectedhavinghighriskindelivery,thepositiverateofscreeningwas6.04%,meanwhile,amongthose520womenwhoarehigh-aged,high-agedwomenwithhigh-riskare163,with31.34%showingpositiv

6、eresult,thehigh-agedpregnantwomenshowedahigherpotentialofbeingpositiveofDown’ssyndromethanthatofwomenoftherightmaternalage(P<0.05).Resultsshowed:8womenhadbeendetectedwithDownssyndrome,including5casesofwhicharehigh-agedwomen,(resultofDown’sscreeningshowing

7、highrisk).Conclusion:UsingtheDown’ssyndromescreeningtotestelderlyprimiparaandgivingprenataldiagnosisbasedontheresultofthatcanimprovethequalityofthepopulation,reducetheincidenceofbirthdefectsinhuman.【keyword】Down’ssyndromescreeningHigh-agedPrimiparaelderlyprimipara

8、Investigation随着社会的发展和人们观念的转变，特别是最近十年来高龄孕国妇所占的妊娠比例越来越高［1］，随着孕妇年龄的增加，胎儿所患染色体病的概率也随着增加，特别是所患唐氏综合症的概率随着增加［2】。本文对高龄孕妇在孕中期行血清学唐氏筛査的应用价值进行探讨，旨在对高龄孕妇提供冇效的产前筛查手段