cvs常用药物概论

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1、CVS常用藥物概論YehYuChang94.06.04.分類Inotropes:強心Chronotropic:增快心律Pressors:升壓Vasodilator:降壓Antiarrhytmicagents:抗心律不整常用藥物Bosmine(Epinephrine)Levophed(Norepinephrine)DopamineDobutaminePrimacor(Milrinone)IsuprelNTGNitroglyceridePerdipineAmiodaronePGE1DDAVPCardiovascularAnatomyCONTR

2、ACTILITYHEARTRATERhythmPRELOADAFTERLOADL/MinCARDIACOUTPUT(CI=CO/m²)CatecholaminesNaturalNorepinephrine:a,b1Epinephrine:a,bDopamine:D,a1,b1(alsosomeNErelease)SyntheticIsoproterenol:bDobutamine:b1(andmixofb2stimulationanda1inhibitionandstimulation)NEEISOEpinephrine0.1-1μg/k

3、g/min1mgin20ml5mg/100ml50kg–0.167μg/kg/minDopamine1-20(50)μg/kg/min400mgin250mL160mg/100mlDobutamine1-20(30)μg/kg/min250mgin100mlIsuprel0.02-0.15μg/kg/min0.2mgin20ml1mg/100mlLevophed0.04-0.4μg/kg/min4mgin50mladult1mgin50mlchildPrimacorIVloading50ug/kgover10minMaintenance0

4、.375-0.75μg/kg/min10mgin10ml50kg–15ml/hrun10minthen1ml/hNTG0.1-4μg/kg/min5mgin10ml50mgin100mlNitroglyceride0.25-10μg/kg/minPerdipine0.5–15mg/h1mg/1mlAmiodaroneAdultIV150mgover10minthen1mg/minfor6hrthen0.5mg/minfor18hr3ampin30mlRun60ml/hfor10minThen4ml/hfor6hThen2ml/hfor18

5、hChild5mg/kgloadingthen5-15μg/kg/min1/2ampin15mlPGE125-250ng/kg/min20μg/powderor500μg/mlDDAVP0.3μg/kgdilutein50mlNSover100ml/h4μg/ml50kgneed15μg4vialin50mlrun100ml/h80kgneed24μg6vialin50mlrun100ml/hμg/kg/min160mgin100ml,50kg(mg/ml)160*1000:mg/ml→μg/ml160*1000/100:100ml→1m

6、l160*1000/100/60:μg/h→μg/min160/6/50=0.533μg/kg/minThanksforyourattention!Haveaniceweekend!Thanksforyourattention!Haveaniceweekend!Thanksforyourattention!Haveaniceweekend!ALPHA-ADRENERGICMEDICATIONSCanbedividedinto:Alpha1-adrenergiceffects:Vascularsmoothmusclecontra

7、ctionAlpha2-adrenergiceffects:Vascularsmoothmusclerelaxation--thisisaverymildeffectonlyatlowdosesofanalpha-adrenergicagentlikeepinephrine.BETA-ADRENERGICMEDICATIONSCanbedividedinto:Beta1-adrenergiceffects:DirectcardiaceffectsInotropy(improvedcardiaccontractility)Chronotro

8、py(increasedheartrate)Beta2-adrenergiceffects:VasodilationBronchodilationEpinephrine1–↑contract