chgangan生化课间绪论1

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1、BiochemistryZhangguangxianPh.Dzhangguangxian@gzhtcm.edu.cnQQ:99811075Tel:13570212885IntroductionWhatistheBiochemistry?Historyanddevelopment?WhatistheBiochemistrydiscussion?BiochemistryandChinesemedicine?BiochemistryDefinition:ThechemistryoflifeThescienceconcernedwiththechemical

2、basisoflifeThescienceconcernedwiththevariousmoleculesthatoccurinlivingcellsandorganismsandwiththeirchemicalreactionAnythingmorethanasuperficialcomprehensionoflife–inallitsdiversemanifestation-demandsaknowledgeofbiochemistryBiochemistryAim:todescribeandexplain,inmolecularterms,a

3、llchemicalprocessesoflivingcellsStructure-functionMetabolismandRegulationHowlifebegan？ThescopeisaswideaslifeitselfBiochemistrySignificance:beessentialtoalllifesciencesasthecommonknowledgeGenetics;Cellbiology;MolecularbiologyPhysiologyandImmunologyPharmacologyandPharmacyToxicolo

4、gy;Pathology;MicrobiologyZoologyandBotanyBiochemistryMedicalstudentswhoacquireasoundknowledgeofbiochemistrywillbeinastrongpositiontodealwithtwocentralconcernsofthehealthsciences:(1)theunderstandingandmaintenanceofhealth(2)theunderstandingandeffectivetreatmentofdiseaseHistoryand

5、development?1903Neuberg首先提出生物化学概念发展：静态—动态—机能生物化学1953WatsonandCrickDNA双螺旋结构（分子生物学）1972Berggeneengineering1976Kan胎前检验beta-地贫1977Shine克隆了人生长激素抑制基因1982Cech发现四膜虫rRNA可自我剪切（Ribozyme）1986MullisPCR技术1990基因治疗进入临床（ADA）2001HGP完成---后基因组学时代---蛋白质组学—生物信息学1903年CarlNeuberg首次提出“生物化学”Apioneerbioc

6、hemist,CarlNeuberg(1877-1956)spentoverthirtyyearsofhisproductivecareerasaprofessorattheUniversityofBerlin(1903-1937)andasDirectoroftheKaiserWilhelmInstitutesofBiochemistryandExperimentalTherapy.Hisvariedresearchinterestsresultedinimportantcontributionstotheunderstandingoffermen

7、tationprocesses,solubilityandtransportphenomenaincells,thechemistryofcarbohydrates,sugars,enzymes,andaminoacids,andphotochemistry.NeubergwasforcedoutofhispositionaftertheNazirisetopower,andtakingrefugeintheUnitedStates.Forthelastseveralyearsofhislife,heworkedatNewYorkUniversity

8、.1953WatsonandCrickDNA双螺旋结构Geneengineering动物克隆转基因PCRfr