chgangan生化课间绪论

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1、优秀精品课件文档资料BiochemistryZhangguangxianPh.Dzhangguangxian@gzhtcm.edu.cnQQ:99811075Tel:13570212885IntroductionWhatistheBiochemistry?Historyanddevelopment?WhatistheBiochemistrydiscussion?BiochemistryandChinesemedicine?BiochemistryDefinition:ThechemistryoflifeThescienceconcernedwiththechemicalba

2、sisoflifeThescienceconcernedwiththevariousmoleculesthatoccurinlivingcellsandorganismsandwiththeirchemicalreactionAnythingmorethanasuperficialcomprehensionoflife–inallitsdiversemanifestation-demandsaknowledgeofbiochemistryBiochemistryAim:todescribeandexplain,inmolecularterms,allchemicalproc

3、essesoflivingcellsStructure-functionMetabolismandRegulationHowlifebegan？ThescopeisaswideaslifeitselfBiochemistrySignificance:beessentialtoalllifesciencesasthecommonknowledgeGenetics;Cellbiology;MolecularbiologyPhysiologyandImmunologyPharmacologyandPharmacyToxicology;Pathology;MicrobiologyZ

4、oologyandBotanyBiochemistryMedicalstudentswhoacquireasoundknowledgeofbiochemistrywillbeinastrongpositiontodealwithtwocentralconcernsofthehealthsciences:(1)theunderstandingandmaintenanceofhealth(2)theunderstandingandeffectivetreatmentofdiseaseHistoryanddevelopment?1903Neuberg首先提出生物化学概念发展：静态

5、—动态—机能生物化学1953WatsonandCrickDNA双螺旋结构（分子生物学）1972Berggeneengineering1976Kan胎前检验beta-地贫1977Shine克隆了人生长激素抑制基因1982Cech发现四膜虫rRNA可自我剪切（Ribozyme）1986MullisPCR技术1990基因治疗进入临床（ADA）2001HGP完成---后基因组学时代---蛋白质组学—生物信息学1903年CarlNeuberg首次提出“生物化学”Apioneerbiochemist,CarlNeuberg(1877-1956)spentoverthirtyyearso

6、fhisproductivecareerasaprofessorattheUniversityofBerlin(1903-1937)andasDirectoroftheKaiserWilhelmInstitutesofBiochemistryandExperimentalTherapy.Hisvariedresearchinterestsresultedinimportantcontributionstotheunderstandingoffermentationprocesses,solubilityandtransportphenomenaincells,thechem

7、istryofcarbohydrates,sugars,enzymes,andaminoacids,andphotochemistry.NeubergwasforcedoutofhispositionaftertheNazirisetopower,andtakingrefugeintheUnitedStates.Forthelastseveralyearsofhislife,heworkedatNewYorkUniversity.1953WatsonandCrickDNA双螺旋结构Geneengineering动物