胃去门静脉循环断流术犬模型的建立论文

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1、胃去门静脉循环断流术犬模型的建立论文赵磊周岩冰李世宽吕亮李宇王亮于冠君【摘要】目的设计胃去门静脉循环断流术的方法，并建立胃去门静脉循环断流术犬模型。方法应用缩窄门静脉主干1/2加丝线慢性栓塞术制作犬肝前型门静脉高压食管静脉曲张模型。然后，实施胃去门静脉循环断流术，即行脾切除后，保留贲门周围血管、食管曲张静脉及迷走神经，从根部离断胃冠状静脉等汇入门静脉系统的胃静脉血管，使胃的静脉血流经门奇间的交通支血管进入体循环。将已形成肝前型门静脉高压食管静脉曲张犬12只随机分为脾切除组、贲门周围血管离断术组、胃去门静脉循环断流术组。于开腹后、手术后即刻及术后3周末测量门静

2、脉及食管曲张静脉压力。术前及术后3周末测定肝功能指标。结果犬模型均存活。手术后即刻及术后3周末与开腹后相比，胃去门静脉循环断流术组门静脉压力显著下降(F=7.386.freelethodofdeportalcirculationdisconnection(DPCD)ofstomachandcreateamodelofDPCDofstomachindog.MethodsAmodelofprehepaticportalhypertensionainportalveinbyplussuturesilktoestablishchronicembolism.Dis

3、connectionofDPCDed,i.e.splenectomyentinportalsystemutilatedattheirbase,resultinginbloodstreamofthestomachflounicatingbranches.The12dogmodelscreatedizedtothreegroupsasgroupA(splenectomy),groupB(mutilationofbloodvesselsurroundingthecardia),andgroupC(DPCDofthestomach).Theportalveinpre

4、ssure(PVP)andvaricoseveinpressure(VVP)easuredatopeningoftheabdomen,immediatelyaftersurgery,andthreeodeldogssurvived.paredmediatelyaftersurgeryandthreeen,thePVPandVVPdecreasedsignificantlyafterDPCD(F=7.386;q=3.503,3.121;P0.05)and(F=8.026;q=3.661,3.240;P0.05),.freelodeldogsofDPCDishi

5、gh,itsprocedureissimple,andqualityisreliable,thismethodisconducivetotheresearchoftheeffectofDPCDonhemodynamicsofportalvein.KEY.7版.北京:人民卫生出版社,2008:17641783.2YANGZ,QIUFZ.PericardialdevascularizationyforthetreatmentofportalhypertensionJ.ChinJSurg,2000,38:645647.3李宗芳,刘效恭,王英,等.缩窄门静脉主干

6、1/2加丝线慢性栓塞术制备犬门静脉高压症模型J.中华实验外科杂志,1997,14(5)：314315.4DEFRANCHISR,PRIMIGNANIM.NaturalhistoryofportalhypertensioninpatientsentOfEsophagealVarices.PredictionofthefirstvaricealhemorrhageinpatientsulticenterstudyJ.NEnglJMed,1988,319(15):983989.6OKUMURAH,ARAMAKIT,KATSUTAY.Pathophysiolog

7、yandepidemiologyofportalhypertensionJ.Drugs,1989,37:212.7VILMAS,ANDRIUSP,DALIAM,etal.HepaticvenouspressuregradientmeasurementinpatientsacologicalreductionofportalpressureandlongtermriskoffirstvaricealbleedinginpatientsJGastroenterol,2006,101:506512.9杨镇,裘法祖.贲门周围血管离断术彻底断流的探讨J.中国实用

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