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ID:26794598
大小:2.61 MB
页数:51页
时间:2018-11-29
《慢性温和非预期应激加重斑秃模型小鼠脱毛及其机制的探讨》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、ThemechanismofalopeciaareatamodelmiceaggravatedbychronicmildunpredictablestressAbstractstainingscoresofVEGFandBFGFofmiceskintissueinMSgroupandMSALgroupweresignificantlyreduced(P<0.05),comparedwithMSSgroup,theimmunohistochemicalstainingscoresofVEGFandBFGFofmiceskint
2、issueinMSALgroupweresignificantlyincreased(P<0.05).Conclusion:1.Externaluseofimiquimodcancausehairloss,whichsuccessfullyestablishedmousemodelofalopeciaareata.2.Chronicmildunpredictablestresscansimulatethebody'sstressresponsewell.3.Chronicmildunpredictablestressaggr
3、avatedhairlossinalopeciaareatamodelmice,promotedfurtherimmunedisordersinmouseskintissue.4.Chronicmildunpredictablestressleadtomicrocirculationdisturbanceinmice,resultinginthatthevasculardensityofskintissuewasreduced,angiogenesisrelevantfactorVEGFandBFGFwasdecreased
4、.5.Alprostadilcanpartiallyreversetheeffectsofchronicmildunpredictablestressinmouseskinmicrocirculation,butnosignificantimprovementinthephenomenonofhairlossinmice.Keywords:Chronicunpredictablemildstress,Alopeciaareata,IFN-γ,TNF-α,MicrocirculationWrittenby:LvQingSupe
5、rvisedby:prof.FuWenqingprof.ZhangGuoxingV目录引言································································································1一、心理应激与斑秃·········································································1二、心理应激与皮肤的免疫紊乱和微循环变化····················
6、···················2三、C3H/HEJ鼠与斑秃······································································3四、研究思路··················································································4第一部分咪喹莫特诱导小鼠斑秃模型的建立············································5一、试剂和仪器·
7、··············································································5二、实验动物和分组·········································································6三、实验方法··················································································6四、实验结果········
8、··········································································7五、讨论··································································
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