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时间:2018-11-27
《腹腔镜保守手术治疗子宫腺肌瘤疗效观察》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、腹腔镜保守手术治疗子宫腺肌瘤疗效观察吕嬿,冷金花,戴毅,史精华,郎景和 摘要:目的探讨子宫腺肌瘤腹腔镜保守手术的临床特点和治疗效果。方法以2004年4月到2007年7月于北京协和医院行腹腔镜子宫腺肌瘤病灶挖除术的72例患者为研究对象,记录其临床特点、辅助治疗、随访结果和妊娠结局,回顾性分析复发和妊娠的相关因素。结果(1)腹腔镜子宫腺肌瘤病灶挖除术后2年,患者痛经程度减轻,子宫体积缩小,血清CA125值下降,和术前相比差异有统计学意义(P<0.05)。(2)术后症状复发率34.7%,复发中位时间30个月。复发组患者的年龄和子宫体积更大
2、,术后妊娠者的复发率低于未妊娠者(P<0.05)。(3)和单纯手术组相比,术后辅助促性腺激素释放激素激动剂(GnRHa)组患者的子宫体积更大、多发腺肌瘤及合并子宫内膜异位症的比例更高(P<0.05),但两组复发率差异无统计学意义。(4)术后妊娠率68.8%,分娩率46.9%。妊娠距离手术的中位时间为13个月。未发现影响妊娠的有统计学意义的临床因素。结论对于有生育要求的局限性腺肌瘤患者,腹腔镜子宫腺肌瘤病灶挖除术能有效缓解症状、促进妊娠。年轻、子宫体积大的患者更容易复发,术后妊娠对复发有保护作用。术后联合GnRHa治疗有助于减少复发,但
3、对妊娠的益处尚不肯定。 关键词:子宫腺肌瘤;腹腔镜;促性腺激素释放激素;复发;妊娠 Themediumtolongtermclinicaloutcomesoflaparoscopicconservativesurgeryonadenomyomas.LYan,LENGJin-hua,DAIYi,SHIJing-hua,LANGJing-he.DepartmentofObstetricsandGynecology,PekingUnionMed-icalCollegeHospital,PekingUnionMedicalCollege
4、,ChineseAcademyofMedicalScience,Beijing100730,ChinaAbstract:ObjectiveToinvestigatetheclinicalcharacteristicsandtreatmenteffectsoflaparoscopicconservativesurgeryonadenomyomas.MethodAtotalof72patientsundergoinglaparoscopicresectionofadenomyomainPekingUnionMe-dialCollegeHo
5、spitalbetweenApril2004andJuly2007werestudiedretrospectively.Thedataofclinicalmanifestation,adjuvanttherapy,follow-upresultsandpregnancyoutcomeswereassessed.Theassociationfactorsofrecurrenceandpregnancywereanalyzed.Result(1)Twoyearsaftersurgery,patientshadstatisticallysi
6、gnificantreliefofdysmenor-rhea,shrinkageofuterinevolumeanddeclineofserumCA125level(P<0.05).(2)Thesymptomrelapseratewas34.7%.Medianintervalbetweensurgeryandrelapsewas30months.Therelapsedpatientswerefeaturedwithstatistical-lysignificantlyyoungerage,largeruterinevolumeandl
7、owerpregnancyratesfollowingsurgery(P<0.05).(3)ThoughthesurgicalfollowedbyGnRHagrouphadstatisticallysignificantlargeruterinevolume,higherratesofmultipleadenomy-omasandconcurrentendometriosis(P<0.05),therelapseratewasnotsignificantlydifferentfromthesurgical-onlygroup.(4)T
8、hepregnancyanddeliveryrateswere68.8%and46.9%,respectively.Medianintervalbetweensurgeryandpregnancywas13months.
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