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1、中国组织工程研究与临床康复第12卷第43期2008–10–21出版JournalofClinicalRehabilitativeTissueEngineeringResearchOctober21,2008Vol.12No.43临床医学自体骨髓间充质干细胞移植治疗阿尔茨海默病4例☆李义召1,2，王庆德3，朱士文2，崔贵祥2，谢克勤2，时庆4，侯怀水4，沈伯钧4AutologousbonemesenchymalstemcelltransplantationforAlzheimer’sdiseasein4casesLiY
2、i-zhao1,2,WangQing-de3,ZhuShi-wen2,CuiGui-xiang2,XieKe-qin2,ShiQing4,HouHuai-shui4,ShenBo-jun41CollegeofPublicHealth,ShandongUniversity,Jinan250012,ShandongProvince,China;2TreatmentCenterofStemCells,GreatwallHospitalofJinan,Jinan250022,ShandongProvince,China;3D
3、epartmentofNeurology,HospitalofShandongAluminiumCorporation,Zibo255069,ShandongProvimce,China;4CordBloodBankofQiluHospital,ShandongUniversity,Jinan250012,ShandongProvince,ChinaLiYi-zhao☆,Doctor,Chiefphysician,CollegeofPublicHealth,ShandongUniversity,Jinan250012
4、,ShandongProvince,China;TreatmentCenterofStemCells,GreatwallHospitalofJinan,Jinan250022,ShandongProvince,Chinayizhaoli888@yahoo.com.cnReceived:2008-01-22Accepted:2008-08-251山东大学公共卫生学院，山东省济南市250012；2济南长城医院干细胞治疗中心，山东省济南市250022；3山东铝业公司医院神经内科，山东省淄博市255069；4山东大学齐鲁医院
5、脐血库，山东省济南市250012李义召☆，男，1964年生，山东省菏泽市人，汉族，2005年山东大学毕业，博士，主任医师，主要从事干细胞治疗神经系统变性疾病研究。yizhaoli888@yahoo.com.cn中图分类号:R394.2文献标识码:A文章编号:1673-8225(2008)43-08431-03收稿日期：2008-01-22修回日期：2008-08-25(08-50-1-594/G·A)Abstract:TenpatientswithAlzheimer’sdiseaseweredividedintost
6、emcelltreatmentinsitugroup(n=6),whichunderwentrecombinedgranulocytecolony-stimulatingfactortreatment(G-CSFgroup),150μg,onceperday,with7-10daysasonetreatmentcourse,combinedwithSalviamiltiorrhizaintravenousinjection(20mL/d)for10days;autologousbonemesenchymalstemc
7、elltreatmentgroup(MSCs,n=4),inwhichbonemarrow(230-330mL)washarvestedfromthepatients’iliaandthenthemononuclearcellswereisolatedbydensitygradientcentrifugation,andthemononuclearcellswereinjectedintravenouslyorintosubarachnoidspacebylumberpunctureonceorseveraltime
8、s.Inaddition,theG-CSFwassubcutaneouslyinjectedonthesameday(stemcelltreatmentinsitu).Beforeandafterstemcelltreatment,mini-mentalstateexamination(MMSE),AbilityofDailyLiving(AD
