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1、氟比洛芬酯对大鼠急性痛的超前镇痛效果论文.freelin经尾静脉给药,C组于造模后即刻经尾静脉给药。2组分别再分为4组(各8只):即生理盐水组、氟比洛芬酯1,3,9mg/kg组;分别于术后2,24,48h进行累积疼痛评分和热板实验,观察注药后反应。结果在动物模型建立前或后给药,氟比洛芬酯均能产生量效相关的抗伤害效应,ED50分别为3.85,4.20mg/kg;95%的置信区间为(3.42,.freelg/kg的抗伤害效应评分及热痛阈在建立模型后2,24,48h时低于C组(P0.05)。结论氟比洛芬酯能产生量效相关抗伤害效应,具有超前镇痛作用。【关键词
2、】氟比洛芬酯;超前镇痛;急性痛ABSTRACT:ObjectiveToobservethepreemptiveanalgesiceffectofpretreatmentofflurbiprofenaxetilonincisionalpaininrats.MethodsAnimalmodeladeaccordingtotheBrennanmethod.Experimentalratslydividedintotaingroups:PandC,eachcontainingfoursubgroups,g/kg,respectively.GroupPrece
3、ivedsalineorflurbiprofenaxetilbeforeincisionandGroupC15minutesafterincisionthroughtailvein.Calculativepainscorcetestandhotplatetestedat2,24and48h.ResultsForbothgroupPandC,flurbiprofenaxetil(1,3,9mg/kg)producedsignificantdose-dependentantinociception.ThevalueofED50g/kgrespective
4、ly.Confidentintervalsg/kgand(3.96,4.44)mg/kg,respectively.Antinociceptionscoreandplantarinistrationofflurbiprofenaxetilthroughtailveincanproducedose-dependentantinociception.Flurbiprofenaxetilhasshoptiveanalgesiceffect.KEY,etal.Theeffectofpre-emptiveLornoxiamandketoprofenapplic
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