长疗程吲哚美辛治疗极低出生体重儿动脉导管开放的疗效论文

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1、长疗程吲哚美辛治疗极低出生体重儿动脉导管开放的疗效论文【摘要】目的：探讨延长吲哚美辛疗程治疗开放性动脉导管（PDA）的疗效和安全性。方法:46例合并PDA早产儿病例随机分为吲哚美辛治疗组24例和布洛芬治疗组22例。吲哚美辛组每次口服吲哚美辛0.2mg/kg，1次/12h，第3次服药后4～12h复查心脏彩色多普勒，PDA关闭者不再服药，未关闭者继续按原剂量服药两次，间隔时间相同，第5次服药后4～12h再次复查心脏彩色多普勒。布洛芬组首次给予10mg/kg，第2、第3次分别为5mg/kg.freelineethacintreatment

2、courseisefficaciousandsafeinclosureofpatentductusarteriosus(PDA)inveryloatureinfantsedbyechocardiographyallthan35ethacin(indomethacingroup),anothergroupinfantsethacingroupinfants,treatmentethacin0.2mg/kgbodyedoseat12hoursintervals.Thenechocardiographyedat4～12hoursafter

3、thethirdtimetakingdrug.IfitentedosesedagaintoconfirmifPDAcloseordonot.Intheibuprofengroupinfants,allbabyreceivedoralibuprofensuspension10mg/kgbodyg/kgeach.EchocardiographyedtodetermineifPDAcloseordonotat4～12hours32～36hoursafterthethirdtimetakingdrug.Serumsodium,serumcr

4、eatinine,plateletcount,serumbilirubineasuredandurineoutputentcourse.Results:Theclosurerateafterthefifthtimetakingmedicineedicine(95.83%vs62.50%,P0.05)inindomethacingroup.Thereethacinandibuprofenethacingroupthanthatinibuprofengroup(95.83%vs68.18%,P0.05).Casesnumbereithe

5、rserumsodiumlomol/LorurineoutputloL/(kg·h)inindomethacingroupberbilirubinreachtophototherapycriteriainibuprofengroupethacingroup(P0.05).Eithergroupnocasesdevelopintestinalperforationornecrotizingenterocolitis.Conclusions:Prolongedoralindomethacincourseiseffectiveandsaf

6、einVLBoragI,BatashD,etal.ClosureofpatentductusarteriosusatureneeireB,SmetsK,LecoutereD,etal.Aparisonofibuprofenandindomethacinforclosureofpatentductusarteriosus［J］.NEnglJMed,2000,343:674681.［5］朴锦善,刁玉霞,苗树馨.口服美林治疗早产儿动脉导管未闭23例［J］.中国新生儿科杂志,21:164165.［6］HerreraC,Holberton

7、J,DavisP.Prolongedversusshortcourseofindomethacinforthetreatmentofpatentductusarteriosusinpreterminfants［J］.CochraneDatabaseSystRev,2004,1:CD003480.［7］BellanderM,LeyD,PolbergerS,etal.Tolerancetoearlyhumanmilkfeedingisnotpromisedbyindomethacininpreterminfantsethacininap

8、reterminfantptomaticpatentductusarteriosus［J］.EurJPediatr,1990,149:651665.［9］NarayananM,SchlueterM,ClymanRI.Incidenc