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1、依贝沙坦与卡托普利联合治疗充血性心力衰竭的疗效论文周泉，胡振玉，吴大方，张同利，钟筱兰【关键词】充血性心力衰竭Captoprilbinedentofdigitalis,diureticsandβblockingagent,lydividedintogroupAandgroupB.GroupA(n=60)g/dandirbesartan75-300mg/dandGroupB(n=60)g/d.ThechangesofNYHAclass,biochemistry,liverfunction,renalfunction,electrocardiogramandechocardiograph
2、yent,leftatrium（LA）diameter,leftventricularenddiastolicdiameter（LVDD）,leftventricularendsystolicdiameter（LVSD）andleftventricularejectionfraction(EF)provedsignificantlyinbothgroups(P0.01).LVDD,LVSDEFandNYHAclassoresignificantingroupAthanthoseingroupB(P0.05).Thereentbetoreeffectivethancaptoprilal
3、oneinthetreatmentofpatientsg/d，卡托普利75~150mg/d；B组(n=60)口服卡托普利50~150mg/d.治疗前后进行心功能NYHA分级评估，行血生化、肝肾功能、心电图、超声心动图检查.结果：治疗12mHg(1mmHg=0.133kPa)及有明显肝肾功能损害者.分为A,.freelg/d，联合口服依贝沙坦（杭州赛诺菲圣德拉堡民生制药有限公司）75~300mg/d.B组口服卡托普利50~150mg,qd.两组药物使用的剂量根据血压和患者耐受情况调整，在患者不出现头昏、头晕、恶心症状，血压稳定、耐受良好时尽量增加卡托普利及伊贝沙坦的剂量.治疗前和治疗后
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6、angiotensinⅡantagonism［J］.JAmCollCardiol，1999；33（5）：1163-1173.［6］吴向明.缬沙坦治疗充血性心力衰竭临床观察［J］.临床心血管病杂志,2001;17(12):557-559..TheclinicalefficacyofValsartanonthetreatmentofcongestiveheartfailure［J］.JClinCardiol,2001;17(12):557-559.［7］CohnJN,TognoniG.Arandomizedtrialoftheangiotensinreceptorblockerirbes
7、artaninchronicheartfailure［J］.NEnglJMed,2001;345:1667-1675.［8］严红，林曙光，陈鲁原，等.氯沙坦与依那普利联用对慢性心力衰竭患者左室功能的影响［J］.中华心血管病杂志，2000；28：230.YanH,LinSG,ChenLY,etal.StudyoftheeffectsofEnalaprilbinedLosartanonleftventricularfunctioninpatientsentof
