资源描述：
《丙型肝炎病毒包膜蛋白e1研究进展论文》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、丙型肝炎病毒包膜蛋白E1研究进展论文【摘要】丙型肝炎是由丙型肝炎病毒(HepatitisCvirus,HCV)感染而引起的严重威胁人类健康的传染病，目前还没有研制成功有效的疫苗。HCV-E1包膜糖蛋白是HCV的结构蛋白之一,具有重要的受体结合位点和抗原表位,在病毒感染和宿主免疫过程中起着十分重要的作用。其分子和功能特性的研究对HCV预防和治疗的研究有重要意义。近年来,有关E1蛋白在机体的免疫应答及其在疫苗研制方面的作用取得了一定的进展,本文就此做一综述。【关键词】丙型肝炎;丙肝病毒；包膜蛋白E1；疫苗AdvancesresearchonHCVE1envelopeprotein【Abst
2、ract】HepatitisC,causedbyhepatitisCvirus(HCV),isanimportantinfectiousdiseasethreateninghumanhealth,andatpresent,therearenovaccinesavailableforpreventingHCVinfection.TheE1envelopeproteinisoneofthestructuralproteinofHCV,havingimportantreceptorbindingsiteandepitope,itplayimportantroleintheprocessofv
3、iralinfectionandimmunity.ThestudyofmolecularandfunctionalcharacterissignificancefordevelopmentofprophylacticandtherapeuticvaccinesagainsthepatitisCvirus.Recentyears,knomuneresponseintheorganism,asaybetooshorttomaximizelong-termresponseamongpatientsinfecteduraH,UyamaH,EnomotoH,etal.Thebinationthe
4、rapyofinterferonandamantadinehydrochlorideforpatientsosM,TrejoO,GarciaM,etal.TripleassociationbeticautoimmunediseasesandBcelllymphoma.JRheumatol,2004,31(3):495-499.5廖小玲，戚中田.丙型肝炎疫苗的研究进展.免疫学杂志,2005，21（3）：25-27.6FornsX,ThimmeR,GovindarajanS.HepatitisCviruslackingthehypervariableregion1oftheseconden
5、velopeproteinisinfectionandcausesacuteresolvingorpersistentinfectioninchimpanzees.ProcNatlAcadSciUSA,2000,97:13318-13323.7SantoliniE,MigliaccioG,LaMonicaN.BiosynthesisandbiochemicalpropertiesofhepatitsCviruscoreprotein.JVirol,1994,68:3631-3641.8DubuhissionJ,RiceCM.HepatitisCVirusglycoproteinfold
6、ing:disuphidebondformationandassociationasJM，MaidensCM，etal.JVirol，1999,73(8):6782-6790.12RosaD,CampagnoliS,MorettoC，etal.ProcNatlAcadSciUSA,1996,93(5):1759-1763.13LaggingLM,MeyerK,Oericglycoproteinsintheinfectivitypseudotypedvirus.JVirol,1998,72:3539-3546.14CiccaglioneAR,MarcantonioC,Costantino
7、A,etal.HepatitisCvirusE1proteininducesmodificationofmembranepermeabilityinE.colicells.Virology,1998,250:1.15RayR,KhannaA,LaggingLM,etal.PeptideimmunogenmimicryofputativeE1glycoproteinspecificepitopesinhepatitisCVirus.JVirol,
