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1、盐酸贝那普利对自发性高血压大鼠肾脏纤维化的影响论文王先梅，杨丽霞，宋武战，齐峰，郭传明，石燕昆，赵颖魏玲，王燕【关键词】血管紧张素转换酶抑制药；肾素【Abstract】AIM:Toobservetheeffectofangiotensinconvertingenzymeinhibitor(benazepril)onintrarenalreninangiotensinsystem(RAS)inspontaneouslyhypertensiverats(SHR)andtoexplorethemechanismbyrenalinterst
2、itialfibrosis.METHODS:Theanimalslydividedinto3groups:spontaneouslyhypertensiveratstreatedethodsofpathologicalexaminationandputerprocessing,therenalcollagenareainkidneyinedbytheimageanalysissystem.Therenallocalangiotensinconvertingenzyme(ACE)activityeasuredbyradioimmuno
3、assay.ThemRNAexpressionsoftypeIandtypeIIIcollagensinrenaltissueerasechainreaction(RT-PCR).RESULTS:Theareaofcollagenol/(minmg)inSHRBgroupand(53.4±8.2)nmol/(minmg)inSHRgroupand(25.3±6.9)nmol/(minmg)in:marker；,RuperezM,EstebanV,etal.MolecularmechanismsofangiotensinIIinduc
4、edvascularinjury［J］.CurrHypertensRep,2003,5（1）:73-79.［2］RuizOrtegaM,RuperezM,EstebanV,etal.AngiotensinII:akeyfactorintheinflammatoryandfibroticresponseinkidneydiseases［J］.NephrolDialTransplant,2006,21(1):16-20.［3］,LorenzoO,BlancoColioLM,etal.Theconnectivetissuegroediat
5、orofangiotensinIIinducedfibrosis［J］.Circulation,2003,108(12):1499-1509.［5］EstebanV,LorenzoO,RuperezM,etal.AngiotensinII,viaAT1andAT2receptorsandNFkappaBpathmatoryresponseinunilateralureteralobstruction［J］.JAmSocNephrol,2004,15(6):1514-1529.［6］GraingerDJ.Transforminggro
6、bVascBiol,2004,24(3):399-404.［7］FerreiraAJ,SantosRA.Cardiovascularactionsofangiotensin(17)［J］.BrazJMedBiolRes,2005,38(4):499-507.［8］MaiaLG,RamosMC,FamandesL,etal.Angiotensin(17)antagonistA779attenuatesthepotentiationofbradykininbycaptoprilinrats［J］.JCardiovascPharmacol
7、,2004,43(5):685-691.
