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1、综述中国组织工程研究与临床康复第13卷第37期2009–09–10出版JournalofClinicalRehabilitativeTissueEngineeringResearchSeptember10,2009Vol.13,No.37组织工程修复骨及软骨缺损的现状及展望***★王秋玲1，吕玉明2，谢德明1Progressandprospectintherepairofboneandosteochondraldefectsbasedonosteochondral
tissueengineeringWangQiu-ling
2、1,LüYu-ming2,XieDe-ming11DepartmentofBiomedicalEngineering,JinanUniversity,Guangzhou510632,GuangdongProvince,China;2DepartmentofOrthopaedics,ThirdAffiliatedHospitalofGuangzhouMedicalCollege,Guangzhou510150,GuangdongProvince,ChinaAbstract:Withthedevelopmentoftissue
3、engineeringtechnology,theconstructionoftissueengineeredosteochondralgrafttorepairtheosteochondraldefectsisbecomingthehighlightinrecentyears.Itstillexistsmanyproblemsintheconstructionofosteochondralgraft,whichneedstobestudiedfurther.Thepurposeofthispaperistoreviewa
4、ndinvestigationprogressontherepairofosteochondraldefectsthroughthekindsofscaffolds,includingthemonolayerandintegrationbilayerscaffolds;sourcesandkindsofseedcells,includingautoallergicandxenogeniccartilageandbonecells,bonemarrowmesenchymalstemcellsandembryonicstemc
5、ell;applicationofbioreactors,andtoputforwardthemainproblemsoftheosteochondralregenerationandtheprospectofosteochondraltissueengineering.WangQL,LüYM,XieDM.Progressandprospectintherepairofboneandosteochondraldefectsbasedonosteochondraltissueengineering.ZhongguoZuzhi
6、GongchengYanjiuyuLinchuangKangfu.2009;13(37):7358-7362.[http://www.crter.cnhttp://en.zglckf.com]WangQiu-ling★,Studyingformaster’sdegree,DepartmentofBiomedicalEngineering,JinanUniversity,Guangzhou510632,GuangdongProvince,ChinaWangqiul1985@163.com摘要：随着组织工程技术的快速发展，组织
7、工程骨软骨复合组织构建修复骨软骨缺损成为研究热点。骨软骨复合组织的构建仍存在很多难题，还需日臻完善。文章从支架材料设计的种类，包括单层和一体化双层支架；种子细胞的来源和类型，包括自体或异体来源软骨及骨细胞、骨髓基质干细胞和胚胎干细胞；生物反应器技术的应用等方面综述了目前骨软骨缺损修复的研究进展，指出组织工程骨软骨修复骨软骨缺损存在的主要问题，并对日后该方面研究的发展方向提出展望。关键词：组织工程；骨软骨；支架；种子细胞；生物反应器doi:10.3969/j.issn.1673-8225.2009.37.033Corresp
8、ondenceto:LüYu-ming,Doctoron-the-job,Associatechiefphysician,DepartmentofOrthopaedics,ThirdAffiliatedHospitalofGuangzhouMedicalCollege,Guangzhou510150,G
