基于重组人生长激素治疗效果下生长激素缺乏症儿童血清ghrelin，nesfatin-1水平变化研究

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1、授予单位代码10089学号或申请号16074中国图书分类号R725HebeiMedicalUniversity硕士学位论文学术学位基于重组人生长激素治疗效果下生长激素缺乏症儿童血清Ghrelin,Nesfatin-1水平变化研究研究生：王玉导师：程亚颖教授专业：儿科学二级学院：河北省人民医院2018年3月目录中文摘要········································································································

2、····1英文摘要···········································································································3英文缩写···········································································································6研究论文基于重组人生长激素治疗效果下生长激素缺乏症儿童血清Ghrel

3、in,Nesfatin-1水平变化研究前言···········································································································7材料与方法····························································································8结果··································

4、·······························································12附图·································································································14附表······························································································1

5、7讨论·······························································································20结论·································································································28参考文献··························································

6、····································28综述Ghrelin及Nesfatin-1与儿童生长激素缺乏症相关性的研究进展······36致谢···········································································································53个人简历································································

7、···································54基于重组人生长激素治疗效果下生长激素缺乏症儿童血清Ghrelin,Nesfatin-1水平变化研究摘要目的：生长激素缺乏症(GHD)是导致儿童矮身材的主要病因之一，是一种由GH分子结构、受体异常或生长激素(GH)分泌或合成部分或完全缺乏等导致的生长发育障碍性疾病。Ghrelin是一种生长激素促分泌素受体(GHS-R)的内源性配体，具有促进生长激素释放的作用。Nesfatin-1是近年来发现的一种新型饱食基因。Ghrelin和Nesfatin-1均参

8、与下丘脑-垂体-性腺轴、能量代谢、摄食及胰岛素分泌的调节，推测两者与GHD密切相关。然而，目前关于重组人生长激素(rhGH)治疗GHD后对Ghrelin及Nesfatin-1的影响还未见报道。本研究观察rhGH治疗前后GHD儿童血清Ghrelin及Nesfatin-1水平的变化及两者之间的相关性，为临床上针对rhGH