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1、授予单位代码10089学号或申请号20153249中国图书分类号R739.4HebeiMedicalUniversity硕士学位论文专业学位神经胶质瘤相关分子病理研究进展研究生：庞世雄导师：焦保华教授专业：外科学二级学院：河北医科大学第二医院2018年3月目录中文摘要··········································································································10英文摘要·····················
2、·····················································································20英文缩写··········································································································30综述神经胶质瘤相关分子病理研究进展··················································5
3、0致谢················································································································25个人简历········································································································26中文摘要神经胶质瘤相关分子病理研究进展摘要神经胶质细胞瘤（gliomas）颅内最
4、常见的肿瘤，根据WHO分类标准指出可以将gliomas根据症状的不同划分成四个等级。其中，Ⅰ、Ⅱ级为低级别胶质瘤，Ⅲ、Ⅳ级为高级别胶质瘤。因为gliomas拥有很高的致死率，所以其在医学界上受到了广泛的关注。而随着相关研究人员研究的深入，人们对于这种疾病的认识也在不断的加深，医学界对胶质瘤的诊断和治疗也已取得了质的飞跃。相比较传统医学中依靠组织学分型，依靠手术为主要治疗手段，术后辅以放化疗的方法对gliomas的治疗起到了不错的效果[1]。在人类基因组计划的完成的前提下，因高通量技术的发展，研究人员提出了在分子病理、分子分型基础
5、上，依据肿瘤形态学并结合基因特征的胶质瘤个体化治疗等概念。因此近年来已发现部分分子标记物可指导胶质瘤临床诊断以及对预后的判断，比如：MGMT、ATRX突变、染色体1p/19q缺失、IDH、TERT启动子区突变、GOLPH3、EGFR、PTPRZ1-MET融合基因及部分micro-RNA等。因此综合以上分子标记物进行分析，可使我们对胶质瘤的发生发展的认识更加深入，并且在临床工作中更有效的指导医学工作者对胶质瘤患者的诊治及判断病人的预后。关键词：分子病理,PTPRZ1-MET融合基因,MGMT,异柠檬酸脱氢酶,染色体1p/19q缺失
6、,端粒酶逆转录酶启动子区突变,GOLPH31英文摘要AdvancesinmolecularpathologyofgliomaABSTRACTThemostcommonintracranialtumorsofgliomas,accordingtotheWHOclassificationcriteria,statethatgliomascanbedividedintofourgradesaccordingtotheirsymptoms.Amongthem,Ⅰ,Ⅱgradelowgradeglioma,Ⅲ,Ⅳgradehighgrad
7、eglioma.Becausegliomashasahighlethalrate,ithasreceivedwidespreadattentioninthemedicalfield.Withthein-depthresearchofrelatedresearchers,people'sawarenessofthisdiseaseisalsoconstantlydeepening,andthemedicalcommunityhasmadeaqualitativeleapinthediagnosisandtreatmentofgli
8、omas.Comparedwithtraditionalmedicinerelyingonhistologicalclassification,relyingonsurgeryasthemaintreatment,postoperativeadjuvantrad
