减毒炭疸芽胞杆菌mnta基因敲除疫苗候选株的构建与评价

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1、５分类号：Ｓ８密级：公开丨Ａｙ＜Ｉ（Ｌ＼硕士学位论文减毒炭疽芽胞杆菌基因敲除疫苗候选株的构建与评价研究生：指导教师：杨百亮教授、刘纯杰研究员专业名称：研究方向：动物传染病的病原学与免疫学＋所二级学院：动物科学ｊ与动物医学学ｐ院二零一四车六月分类号：S85密级：公开硕士学位论文减毒炭疽芽胞杆菌mntA基因敲除疫苗候选株的构建与评价研究生：刁立鹏指导教师：杨百亮教授、刘纯杰研究员专业名称：预防兽医学研究方向：动物传染病的病原学与免疫学所在二级学院：动物科学与动物医学学院二零一四年六月TianjinAgriculturalUniv

2、ersityDissertationforMasterConstructionandevaluationofanovelmntAmutantvaccinecandidateofBacillusanthracisCandidate：DiaoLipengSupervisor：Prof.YangBailiangProf.LiuchunjieSpeciality：PreventiveVeterinaryMedicineResearchField：Theaetiologyandimmunologyofanimalinfectiousdisease2014.06目录摘要..........

3、..................................................................................................................................VAbstract...................................................................................................................................VII第一章引言..............

4、.................................................................................................................11炭疽及炭疽芽胞杆菌.............................................................................................................12炭疽芽胞杆菌的毒力................................................

5、.............................................................43炭疽芽胞杆菌疫苗.................................................................................................................54口服疫苗......................................................................................................

6、...........................65芽胞疫苗载体.........................................................................................................................76mntA基因及其编码的蛋白....................................................................................................77基因敲除...............

7、..................................................................................................................98研究的目的和意义.................................................................................................................9第二章疫苗候选株的构