自噬在n-乙酰半胱氨酸萝卜硫素抗胶质母细胞瘤中的作用及其机制研究

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1、授予单位代码10089学号或申请号20151010中国图书分类号R322.8HebeiMedicalUniversity博士学位论文学术学位自噬在N-乙酰半胱氨酸萝卜硫素抗胶质母细胞瘤中的作用及其机制研究研究生：刘汉杰导师：崔慧先教授专业：人体解剖与组织胚胎学二级学院：基础医学院2018年4月学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的

2、专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。研究生签名：导师签章：二级学院领导盖章：年月日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：导师签章：年月日目录中文摘要········································································································1英文摘要

3、········································································································7英文缩写········································································································15研究论文自噬在N-乙酰半胱氨酸萝卜硫素抗胶质母细胞瘤中的作用及其机制研究引言········································

4、································································17第一部分N-乙酰半胱氨酸萝卜硫素通过自噬调节胶质母细胞瘤U87MG和U373MG细胞中α-tubulin表达水平前言········································································································19材料与方法··························································

5、··································21结果········································································································36附图········································································································40讨论·······································

6、·································································48小结········································································································50参考文献································································································50第二部分N-乙酰半胱氨酸萝卜硫素

7、诱导的细胞自噬调节胶质母细胞瘤U87MG和U373MG细胞侵润和凋亡前言········································································································54材料与方法····························································································55结