cd44v9在胃癌进展过程中的表达及其意义

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1、授予单位代码10089学号或申请号20153144中国图书分类号R735.2HebeiMedicalUniversity硕士学位论文专业学位CD44v9在胃癌进展过程中的表达及其意义研究生：王凯悦导师：刘丽教授专业：内科学二级学院：河北医科大学第二医院2018年3月目录中文摘要······································································································1英文摘要····················

2、···········································································2英文缩写·····································································································4研究论文CD44v9在胃癌进展过程中的表达及其意义前言·························································

3、··············································5材料与方法························································································6结果·········································································································9附图···············

4、··························································································11附表···································································································14讨论·····································································

5、···························17结论·································································································19参考文献·····························································································19综述CD44v9在胃癌中的研究进展····················

6、·········································21致谢······································································································32个人简历···························································································33中文摘要CD44v9在胃癌进展过程中的表

7、达及其意义摘要目的：研究CD44v9在胃癌进展过程中的表达及其意义。方法：收集于我院胃镜室行ESD术后早期胃癌30例、胃肠外科术后进展期胃癌30例及相应癌旁正常组织30例。HE染色观察胃癌组织病理学表现，免疫组化测定癌旁正常组织、早期胃癌、进展期胃癌CD44v9的表达。表达差异应用t检验比较。结果：1.病例资料HE染色：早癌：高分化腺癌23例，中分化腺癌7例；进展期胃癌：中分化腺癌11例，低分化腺癌16例，粘液腺癌2例，印戒细胞癌1例。2.胃组织免疫组化结果据免疫组化结果，CD44v9主要定位于细胞膜，小部分定位于细胞浆。在胃

8、癌组织中，CD44v9大多呈阳性表达，光密度（OD）值为（0.232±0.096），癌旁正常组织不表达，光密度（OD）值为0，胃癌组织的OD值明显高于癌旁正常组织，差异有统计学意义（P<0.01）。早期胃癌组织CD44v9大多呈阳性表达，光密度（OD）值（0.280±0.11