水飞蓟宾诱导细胞自噬改善高果糖所致hepg2细胞脂质沉积的作用及机制

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1、授予单位代码10089学号或申请号20152034中国图书分类号R589.2HebeiMedicalUniversity硕士学位论文学术学位水飞蓟宾诱导细胞自噬改善高果糖所致HepG2细胞脂质沉积的作用及机制研究生：李洋导师：任路平副教授宋光耀教授专业：内科学（内分泌与代谢病学）二级学院：河北省人民医院2018年3月目录中文摘要············································································································1英文摘要····················

2、························································································3英文缩写············································································································5研究论文水飞蓟宾诱导细胞自噬改善高果糖所致HepG2细胞脂质沉积的作用及机制前言························································

3、····················································6材料与方法································································································8结果··········································································································21附图·······························

4、···········································································23讨论··········································································································30结论··········································································································34参

5、考文献··································································································35综述自噬与肝脏脂代谢················································································40致谢·····································································································

6、·············50个人简历··········································································································51中文摘要水飞蓟宾诱导细胞自噬改善高果糖所致HepG2细胞脂质沉积的作用及机制摘要近年来许多研究表明，细胞自噬与个体发育、氧化性损伤保护、肿瘤细胞的恶性增殖及神经退行性疾病有关。最近的研究表明自噬与脂代谢有关，肝脏是脂代谢的关键部位，脂代谢异常会引起肥胖相关疾病，如非酒精性脂肪肝病（NonalcoholicFattyLiverDisease,

7、NAFLD）、2型糖尿病、代谢综合征等。水飞蓟宾是一种从植物中提取的黄酮类化合物，具有保肝、降血脂、抗肝硬化、提高机体免疫力、抗氧化、保护心肌等作用，在临床试验研究中表明水飞蓟宾可以改善肝脏脂质沉积，改善胰岛素敏感性，但具体机制不明。本研究拟以HepG2细胞为研究对象，研究水飞蓟宾对高果糖诱导HepG2细胞脂质沉积的改变及对自噬水平的影响，探讨水飞蓟宾改善脂质沉积及自噬水平的作用机制，为临床用药提供实验基础及理论依据。目