食管鳞状细胞癌中cdh11和mkl1的表达及其临床意义

《食管鳞状细胞癌中cdh11和mkl1的表达及其临床意义》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、授予单位代码10089学号或申请号15106中国图书分类号R735.1HebeiMedicalUniversity硕士学位论文学术学位食管鳞状细胞癌中CDH11和MKL1的表达及其临床意义研究生：梁婕导师：董稚明教授专业：病理学与病理生理学二级学院：河北医科大学第四医院2018年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单

2、位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。研究生签名：导师签章：二级学院领导盖章：年月日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：导师签章：年月日目录中文摘要····································································

3、··········1英文摘要··············································································4英文缩写··············································································8研究论文食管鳞状细胞癌中CDH11和MKL1的表达及其临床意义前言·······························································

4、···············9材料与方法····································································10结果·············································································13附图·············································································15附表··················

5、···························································22讨论·············································································27结论·············································································30参考文献··············································

6、·························30综述钙黏附蛋白家族在恶性肿瘤的发生发展中的研究进展···········33致谢···················································································46个人简历·············································································47食管鳞状细胞癌中CDH11和MKL1的表达及其临床意义摘要目的:食管癌是消化

7、系统常见恶性肿瘤之一，发病率和死亡率一直居高不下，严重危害着人类健康。由于食管癌早期发病症状不明显，导致病人就医延迟，大多数病人术后5年内复发，生存率低。因此，研究食管癌的发病机制并控制其发生发展，是目前迫切需要解决的临床难题。临床上需要能准确预测和判断食管鳞状细胞癌（esophagealsquamouscellcarcinoma，ESCC）侵袭、转移的分子标志物，帮助指导手术方案的确定和术后治疗的选择，以提高食管癌患者的术后生存率及生存质量。钙黏附蛋白是一种单链跨膜糖蛋白，研究发现，Ⅱ型成骨细胞型钙黏附蛋白（Cadherin-11，CDH

8、11）在多种上皮细胞源性肿瘤中异常表达，但有关CDH11在食管鳞状细胞癌的研究尚未发现。心肌相关转录因子A(MRTF-A或MKL1)属于转录因子的MRTF家族，是转录调控激活辅助