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1、低分子肝素联合丹参多酚酸盐对肺心病急性加重期的疗效观察四川省内江市东兴区人民医院呼吸内科四川内江641000【摘要】目的:观察低分子肝素联合丹参多酚酸盐对肺心病急性加重期的治疗效果。方法:对46例肺心病急性加重期的患者随机分为治疗组(16例),肝素组(16例),对照组(14例),3组均给予常规治疗;肝素组同时给予低分子肝素钙5000iu皮K注射,每口一次;治疗组予低分子肝素钙5000iu皮下注射,丹参多酚酸盐50mg静脉滴注,每口一次以7天为一疗程。观察3组疗效、血气分析和血液流变学指标变化。结果:治疗组总有效率87.5%,
2、肝素组81.25%,对照组71.43%,3组之间疗效两两比较有统计学差异(P<0.05)o治疗组、肝素组治疗前后动脉血氧分压(PaO2)有统计学差异(P<0.05),两组与对照组比较治疗后PaO2有统计学差异(P<0.05)o血液流变学指标纤维蛋白原、红细胞比容、INR治疗前后有统计学差异(P<0.05>。结论:低分子肝素联合丹参多酚酸盐对肺心病急性加重期患者有一定疗效,但与肝素组比较PaO2及血液流变学指标改变无统计学意义。【屮图分类号1R256.1【文献标识码】B【文章编号11674-8999(2
3、015)6-0024-01[Abstract]Objective:Toobservethelowmolecularweightheparincombinedwithsalvianolatetreatmenteffectofacutestageofcorpulmonale.Methods:46casesofacuteexacerbationofchronicpulmonaryheartdiseasewererandomlydividedintotreatmentgroup(16cases),heparingroup(16cas
4、es),controlgroup(14cases),3groupsweregivenconventionaltherapy;heparingroupwasgivenlowmolecularheparincalcium5000iusubcutaneousinjection,onceaday;thetreatmentgroupwastreatedwithlowmolecularweightheparincalcium5000iusubcutaneousinjection,salvianolate50mgintravenousdr
5、ip,onceadayfor7daysforacourseoftreatment.Toobservethetherapeuticeffectofthe3groups,bloodgasanalysisandbloodrheologyindexes.Results:thetotaleffectiveratewas87.5%inthetreatmentgroup,heparingroup81.25%,controlgroup71.43%,3groupsofcurativeeffectbetweenthetwotwowasstati
6、sticallysignificant(P<O.O5).Beforeandafterthetreatmentgroupandtheheparingroup,arterialpartialpressureofoxygen(PaO2)hadsignificantdifference(P<0.05),thetwogroupcomparedwiththecontrolgroupaftertreatment,thereweresignificantdifferencesinPaO2(P<0.05).Therewass
7、ignificantdifferencebeforeandafterthebloodrheology,fibrinogen,hematocrit,INRtreatment(P<0.05).Theconclusionhascertaincurativeeffectoflowmolecularweightheparincombinedwithsalvianolateinpatientswithacuteexacerbationofchronicpulmonaryheartdisease,butwiththeheparing
8、roupPaO2andhemorheologyindexeshadnostatisticalsignificance.随着社会的发展,慢阻肺发病率高居于呼吸内科第一位,苏并发症肺心病给病人及其家庭带来严重的经济负担,也给社会带来了沉重的负担。国内较多研究报道指出丹参多酚酸盐对冠心病具有确切