慢性乙肝肝硬化患者背侧丘脑的二维氢质子磁共振波谱成像

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1、硕士学位论文ProtonMRspectroscopyimagingofthe‘ll●。-‘●J_一·-一·thalamusInpatientsWlthlivercirrhosisresultingfromchronichepatitisBName：PengJun--pingSupervisor：Prof．ZhangXue—linABSTRACTobjective：1．Toexplorethevalueof2D-1HMRSinthalamusofpatientswithcllromchepaticcirrho

2、sis(CHC)；3．ToexploretheneuropsychologicaldisfunctionofCHCpatients，andbycorrelatingitwith2D-HMRS，tostudythepathogenesisofthesechanges．．MaterialandMethod：1．SubjectsConventional1．5TMRISCanand1H．^很Sexaminationswereperformedinall28casesofCHCpatients(hepaticcirr

3、hosisgroup，He)and23volunteers(controlgroup)duringAprilof201toNovemberof201inthe或Lrneperiod．，n圮24malesand4femalesoftheHCgroup，aged27^石1years，wereinfectedbyhepatitisBvirus(FraY)，andthecollrseofdiseaserangesfrom9monthto31years．Accordingtoacompatibleliverbiops

4、yorclearevidenceofliverfailureandcomplicationsassociated晰tllportalhypertensiondocumented，allpatietientswereconsideredascirrhosisandclassifiedintoChildA(n=l1)，B(n=l1)orC(n_6)inaccordance诵tllclinicalmaterials．mcontrolgroupWasstrictlyselectedinlinewiththeCHCg

5、roup，whichrecruitedhealthyindividuals、^，ithallequivalenteducation"level，thesamegenderandnearagethatthegapwaslessthan3years．ExclusioncriteriaforallABSTRACTparticipantsincludedhypertention,otherpotentialcausesofneuropsychiatricabnormalities，forexample，concom

6、itantneurologicaldisorderssuchassubduralhaematoma,cerebralinfartion，severeleukoaraiosisandWemicke’Ssyndrome，othermetabolicabnormalitiessuchaselectrolyteimbalance，diabetesmellitusandintoxication、航thalcoholordrugs．2．NeuropsychologicalExaminationsCommissioned

7、bytheOrganisationMondialedeGastroente7rologie，theWorkingPartyreachedaconsensusinthedefinitionofHEandpresenteditatthellthW．0ddCongressofGastroenterologytwcoo)inVienna,1998．In2002，theWorkingPartypresentedtheirfinalreport,suggestingamodificationofnomenclature

8、forclinicaldiagnosisofHE，，whichcontainstheresultof4neuropsychologicaltests：NumberConnectionTestsAandB(NCTA，B)，Digit-Symbol(DST)，andBloFk-DesignTest(BDT)．Theysuggestedthatpatientsperformingabnormallyin2ormoret