射频透热在腹腔灌注奥沙利铂、金葡素治疗恶性腹水中疗效观察

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1、射频透热在腹腔灌注奥沙利铂、金葡素治疗恶性腹水中疗效观察张为强王玉树赵仔君王玮周聆上海市闸北区市北医院200435【摘要】①A的：探讨射频透热治疗在腹腔灌注奥沙利铂、金葡素治疗恶性腹水屮的治疗效果。②方法：病人分为治疗组和对照组A、B组，其屮治疗组30例，腹腔内注入金葡素80ml、奥沙利铀200mg/m2+5%葡萄糖水100ml，地塞米松10mg及利卡因10ml；即行射频热疗，一周3次。对照组A组30例，腹腔内注入金葡素80ml、奥沙利怕200mg/m2+5%葡萄糖水100ml，地塞米松10mg及利卡因10ml。对照组B组30例，腹水引流后即行腹腔

2、射频热疗，一周3次。③结果：治疗组和对照组A、B治疗腹水的有效率分别为80.0%,53.33%,13.33%,治疗组与对照组之间比较差异有显著性(P<0.05)；对照组A与对照组B之间比较差异有显著性(P<0.05)o④结论：射频透热治疗可提高腹腔灌注奥沙利铂、金葡素治疗恶性腹水的治疗效果。【关键词】射频透热：恶性腹水：金葡素：奥沙利铂Studyofradiofrequencyhyperthermiacombinedwithintraperitonealinfusionofstaphyiococcusenterotoxinandoxal

3、iplatininthetreatmentofmalignantascitesZhangWeiqiang，WangYuesu,ZhaoZijun,Wangwei,ZhoulinDepartmentofOncology,ShanghaiZhabeiHospital,Shanghai200435,China[AbstractJObjective：Toevaluatethetherapeuticeffectsandadversereactionofradiofrequencyhyperthermiacombinedwithintraperitoneali

4、nfusionofstaphyiococcusenterotoxin(SE)andoxaliplatin(Oxa)inthetreatmentofmalignantascites.Methods：Atotalof90caseswithmalignantascitesweredividedinto3groups.Thetreatmentgroup(n=30)wastreatedwithSEandoxaliplatinandradiofrequencyhyperthermia.ThecontrolgroupA(n=30)wastreatedwithSE

5、andoxaliplatin.ThecontrolgroupB(n=30)wastreatedwithradiofrequencyhyperthermia.Results：Forthetreatmentgroup，CR+PR80%；thecontrolgroupA，CR+PR53.33%.thecontrolgroupB,CR+PR13.33%.Thereweresignificantdifferencesbetweenthetreatmentgroupandthecontrolgroups(P<0.05).Thereweresignific

6、antdifferencesbetweenthegroupAandthegroupB(P<0.05).CombinedusewithSEandOxaandhyperthermiadidnotincreasethetoxicity.Conclusion：Radiofrequencyhyperthermiacombinedwiththeintraperitonealinfusionofstaphyiococcusenterotoxin(SE)andoxaliplatininthetreatmentofmalignantascitesissigni

7、ficantlymoreeffectivethanthatwithstaphyiococcusenterotoxin(SE)andoxaliplatinorradiofrequencyhyperthermiaonly.[Kwywords]radiofrequencyhyperthermia；staphyiococcusenterotoxin；oxaliplatin；malignantascites【中图分类号】RH834【文献标识码】A【文章编号】2096-0867(2016)-05-149-02恶性腹水是晚期恶性肿瘤常见并发症，大量腹水严重影响患

8、者的生活质量。因恶性腹水的产生机制尚未明确，目前还没冇较冇效的治疗方法。临床上治疗恶性腹水的方法主要有利尿剂、腹腔穿刺排液