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1、血液高凝状态与活动性UC病情分级、转归的相关性研究岳阳县人民医院湖南岳阳414100【摘要】目的探讨血液高凝状态与活动性溃疡性结肠炎(UC)病情分级、转归的相关性。方法收集2013年1月至2015年10月我院收治的活动性UC患者66例，同时选取同期来我院接受健康体检的体检者20例，比较不同严重程度UC患者和健康体检者血D-二聚体水平，同时将66例活动性UC患者随机平分为两组，对照组(n=33)接受常规UC治疗，观察组(n=33)在接受常规UC治疗之前，先进行抗凝治疗，比较两组患者治疗前后血D-二聚体水平和UC治疗效果。结果UC重度活动组患者的血D-二聚体水平为521.32±
2、;57.49mg/L；中度活动组患者为357.94±49.88mg/L；轻度活动组患者为226.05±41.94mg/L；健康体检组为148.39±55.39mg/L,组间差异具有统计学意义，P<0.05；观察组患者治疗后血D-二聚体水平为212.94±60.76mg/L,对照组为275.93±56.83mg/L,P<0.05；观察组患者治疗有效率为87.88%,对照组为69.70%,P<0.05。结论血液的高凝状态与活动性UC病情严重程度呈正相关，控制UC患者的血液高凝状态，对于提高患者的治疗效果
3、具有积极作用，值得推广应用。【关键词】血液；高凝状态；活动性；溃疡性结肠炎；病情分级；转归[Abstract]objectivetoinvestigatethebloodcoagulationstateandhighactiveulcerativecolitis(UC)classificationconditions,andtheoutcomeofthecorrelation.CollectedfromJanuary2013toOctober2015,ourhospital66casesofpatientswithactiveUC,andatthesametimetothehospit
4、altoacceptphysicalexaminationexaminationof20cases,andcomparisonofdifferentseverityinpatientswithUCandhealthycheck-upbloodD-dimerlevel,atthesametimewillbe66activeUCpatientsrandomlydividedintotwogroups,controlgroup(n=33)treatedwithconventionalUC,observationgroup(n=33)beforeacceptingroutineUCtreatm
5、enttoanticoagulation，comparedtwogroupsofpatientsbeforeandaftertreatmentthebloodD-dimerlevelandUCtreatment.ResultsbloodgroupofpatientswithsevereUCactivityD-dimerlevelwas521.32+/-57.49mg/L；Patientswithmoderateactivitygroupwas357.94+/-49.88mg/L；Mildactivitygroupsofpatientswas226.05+/-41.94mg/L；Heal
6、thTiJianZuwas148.39+/-55.39mg/L,statisticallysignificantdifferencesbetweengroups,P<0.05；ObservationgroupofpatientsaftertreatmentthebloodD-dimerlevelwas212.94+/-60.76mg/L,275.93+/-56.83mg/L,thecontrolgroup(P<0.05；Observationgroupofpatientstreatmenteffectiverateof87.88%,69.70%,thecontrolgrou
7、p(P<0.05.ConclusionbloodhighcondensationstatepositivelycorrelatedwithactiveUCillnessseverity,controlofhighbloodcoagulationstateinpatientswithUC，playsapositiveroletoimprovethetherapeuticeffectofpatients，isworthyofpopulariz
