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1、清hsCRP水平及糖尿病冠状动脉弥漫病变关系探析分类号:R587.1文献标识码：A文章编V：1009_816X(2010)03_0174_03IncreasedSerumHighSensitivityC_reactiveProteinLevelisAssociatedwithDiffuseCoronaryArteryLesionsinPatientswithType2Diabetes.WUMei_cui,LULin,LINZu_jin.DepartmentofCardiology,TaizhouCentralHospitai,Zh
2、ejiang318000,China[Abstract]ObjectiveTheaimofthisstudywastodeterminetheprognosticvalueofhighsensitivityC_reactiveprotein(hsCRP)fordiffusecoronaryarterylesionsinpatientswithtype2diabetes.MethodsAtotalof296patientswithcoronaryarterydisease(CAD)confirmedbyangiographywere
3、dividedinto5groupsbaseduponcoronaryangiographicfindingsandwithorwithoutdiabetes：92patientshadfocalcoronaryarterylesionswithoutdiabetic(groupI)，78patientshaddiffusecoronaryarterylesionswithoutdiabetes(groupII),30patientshaddiabetesbutnotCAD(groupIII),32diabeticpatients
4、withfocalcoronaryarterylesions(groupIV)；and64diabeticpatientswithdiffusecoronaryarterylesions(groupV),SerumlevelsofhsCRP,TNF_aandIL_6weremeasuredinallsubjects.ResultsSerumhsCRPlevelwassignificantlyhigher(p<0.01)ingroupVthanthatinotherfourgroups(14.65±8.74vs.7.78±5.91，
5、9.16±8.13,7.47±4.62,10.58±7.43mg/L),andSerumhsCRPlevelingroupIVwassignificantly(p<0.05)higherthanthatingroupIandgroupIII.IL_6levelwassignificantly(p<0.05)higherthatingroupVthaningroupIIandgroupIII.ThelevelofTNF_aingroupIVwassignificantly(p<0.05)higherthanthatingroupII
6、andgroupIII.ThelevelsofIL_6ingroupIVandTNF_aingroupVwerehigherthanthoseingroupl,IIandIII,buttherewasnosignificantlydifference.TherewasnosignificantlydifferenceforthelevelsofhsCRP,IL_6andTNF_abetweengroupIandgroupII.hsCRPwaspositivecorrelationwithdiffusecoronaryarteryl
7、esionsanddiabetic.ConclusionsIncreasedserumhsCRPlevelinpatientswithtype2diabeteisanimportantriskfactorfordiabeticatherosclerosiscomplication,futhermoreitisassociatedwiththeextentandseverityofcoronaryarterylesionsintype2diabetes.[Keywords]C_reactiveprotein；Diabetesmell
8、itus；Diffusecoronaryarterylesions糖尿病是冠心病的主要危险因素，合并糖尿病的冠心病患者冠状动脉病变以多支弥漫病变多见且预后较差［1，2］。近年来研究认为，糖尿病和动脉硬化均为低度炎症性疾病［3］。冠心病或糖尿病患者血
