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1、结核性脑膜炎患儿脑脊髓液中腺苷脱氨活性测定临床意义【摘要】目的：评价结核性脑膜炎患儿脑脊髓液中腺苷脱氨酶(CSF-ADA)活性对临床诊断意义及疗效判断价值。方法:选择122例住院患儿为研究对象，56例结核性脑膜炎患者为A组;66例非结核性脑膜炎患者为对照组，其中细菌性脑膜炎32例为B组，病毒性脑膜炎34例为C组，采用酶耦联Trinder法测定患儿治疗前CSF-ADA活性，56例结核性脑膜炎患儿于抗结核治疗后2周和6周时分别检测CSF-ADAo结果:A组CSF-ADA活性为(11.8±4.4)U/L，B组为(6.1土2.8)U/L,C组为(4.
2、9±3.1)U/L，与A组比较差异有统计学意义(F=45.150，P=0.000)。取CSF-ADA^8U/L作为临界值时鉴别结核性脑膜炎与非结核性脑膜炎价值最高，灵敏度为87.72%，特异度为90.77%。随着患儿病情好转，CSF-ADA活性逐渐降低。结论:CSF-ADA活性彡8U/L可作为诊断结核性脑膜炎的一项辅助诊断指标，抗结核治疗后CSF-ADA活性可作为疗效判断的参考指标。【关键词】腺苷脱氨酶；脑膜炎；结核；脑脊髓液ClinicalSignificanceofCerebrospinalFluidAdenosineDeaminaseo
3、fChildrenwithTuberculousMeningitis/CHENGJin-ling.//MedicalInnovationofChina,2012,9(33)：027-028[Abstract]Objective：Evaluationoftuberculousmeningitiswithcerebrospinalfluidofadenosinedeaminase(CSF-ADA)activitytoclinicaldiagnosissignificanceandeffectofvaluejudgment.Method：Tocho
4、ose122caseshospitalizedchildrenastheresearchobject,56casesoftuberculousmeningitiswasthecasegroup(groupA).66casesofmeningitisofn/medtuberculosissexascontrolgroup,includingbacterialmeningitis32cases(groupB),andviralmeningitis34cases(Cgroup),usingenzymecouplingTrinderspectrome
5、trytoanalyzeCSF-ADAactivitybeforetreatment.56casesoftuberculousmeningitisinantituberculartreatmentchildrenafter2weeksandsixweeksrespectivelydetectionCSF-ADA.Result：TheCSF-ADAactivityofgroupAwas(11.8±4.4)U/L,comparedwithgroupB(6.1+2.8)U/L,groupC(4.9±3.1)U/L,therewasasignific
6、antdifferencemeaning(F=45.150,P=0.000).TakingtheCSF-ADA^8U/Lascriticalvalueinidentificationoftuberculousmeningitishadthehighestvalue,andsensitivitywas87.72%andspecificitywas90.77%.Aspatientsimproved,CSF-ADAactivitygraduallyreduced.Conclusion：CSF-ADAactivitywas8U/Lcanbeuseda
7、saauxiliarydiagnosisindexoftuberculousmeningitis,CSF-ADAactivitycanbeusedascurativeeffectjudgmentreferenceindex.【Keywords]Adenosinedeaminase；Meningitis；Tuberculosis；CerebrospinalfluidFirst-authorsaddress：RunanPeoplesHospital,Runan463300,Chinadoi：10.3969/j.issn.1674-4985.201
8、2.33.015结核性脑膜炎(tuberculousmeningitis,TBM)属于重症肺外结核，是由结核分枝杆菌引起的中枢神经系统感染性疾病，其病死率和致残率较
