复合辅酶联合二丁酰环磷腺苷钙治疗非st段抬高性心肌梗死的效果观察

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1、复合辅酶联合二丁酰环磷腺苷钙治疗非ST段抬高性心肌梗死的效果观察［摘要］目的研宄复合辅酶联合二丁酰环磷腺苷钙治疗非ST段抬高性心肌梗死（NSTEMI）的效果。方法选择2013年1〜12月我院住院NSTEMI患者60例，随机分成对照组和治疗组，对照组给予抗血小板、抗凝、ACEI（或ARB）、卜受体阻滞剂等常规治疗，治疗组在常规治疗上给予复合辅酶（200U,1次/d，静脉滴注）联合二丁酰环磷腺苷钙（40mg，1次/d，静脉滴注）治疗2周。记录治疗前后肌酸激酶同工酶（CK-MB）、肌钙蛋白l（cTnl）、高敏C反应蛋白（hs-CRP）、血浆B型脑钠肽（BNP）、超声心动图（UCG

2、）参数中射血分数（LVEF）、左室舒张末期内径（LVEDD）结果，比较两组参数间的差别。结果治疗组接受复合辅酶联合二丁酰环磷腺苷钙治疗后CK-MB、cTnl、hs-CRP、BNP值明显低于对照组，差异有统计学意义（P［关键词］复合辅酶；二丁酰环磷腺苷钙；非ST段抬高心肌梗死；脑納肱；左室收缩功能［中图分类号］R541［文献标识码］A［文章编号］1674-4721（2015）08（b）-0131-04Effectobservationofcoenzymecomplexcombinedwithcalciumdibutyryladenosinecyclophosph-ateint

3、hetreatmentofnon-ST-segmentelevationmyocardialinfarctionLIYong-zhengZHANGQing-fengADepartmentoftheSecondInternalMedicine,CityCentralPeople’sHospitalinZaozhuangCityofShandongProvince，Zaozhuang277100，China[Abstract]ObjectiveTostudytheeffectofcoenzymecomplexcombinedwithcalciumdibutyryladenosi

4、necyclophosph-ateontreatingpatientswithnon-STsegmentelevationmyocardialinfarction(NSTEMI).MethodsSixtyhospitalizedNSTEMIpatientsinourhospitalfromJanuarytoDecember2013wererandomlydividedintocontrolgroupandtreatmentgroup.lnthecontrolgroup,conventionaltherapieslikeantiplatelet，anticoagulation

5、,angiotensinconvertingenzymeinhibitor(ACEI)(orARB),and3-receptorblocker，etc.wereprovided,whileinthetreatmentgroup,coenzymecomplex(200U,1times/d，intravenousdrip)combinedwithcalciumdibutyryladenosinecyclophosph-ate(40mg,1times/d，intravenousdrip)wasadded.Thecoursesoftreatmentlasted2weeks.Para

6、metersincludingcreatinekinase-MB(CK-MB)，troponinl(cTnl)，high-sensitivityC-reactiveprotein(hs-CRP)，plasmatype-Bbrainnatriureticpeptide(BNP),ultrasoniccardiogram(UCG)whichreflectedleftventricularejectionfraction(LVEF)andleftventricularend-diastolicdimension(LVEDD)beforeandaftertreatmentwerer

7、ecordedandcompared.ResultsIncomparisonswiththetreatmentgroupandcontrolgroup，thevaluesofCK-MB，cTnl，hs-CRP，andBNPaftertherapyinthetreatmentgroupwasmuchlowerthanthatinthecontrolgrouprespectively，withstatisticaldifferences(P[Keywords]Coenzymecomplex；CalciumDibutyr