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1、EnvironmentalDriversofChronicDiseaseBasedonthereportEnvironmentalThreatstoHealthyAgingbyJillSteinMD,TedSchettlerMD,MPH,MariaValentiandBenRohrer2010GreaterBostonPhysiciansforSocialResponsibility(www.psr.org/Boston)andTheScienceandEnvironmentalHealthNetwork(www.sehn.org)WhatWeWillCoverEn
2、vironmentalfactorsarekeydriversofmanycommonchronicdiseasesEnvironmentalfactorsalterkeybiologicalpathwaysleadingtochronicdiseaseImportantenvironmentaldeterminantsofhealthinclude:Foodsystem/nutritionanddietToxicchemicalsBuiltenvironment/physicalactivityPsychological&socioeconomicstressEx
3、amplesofcrosscuttingsolutionsforhealthypeople&ahealthyenvironmentScope&ContextoftheProblemAcenturyofchangeinnatural,builtandsocialenvironmentshascausedmajorchangesinthepatternsanddistributionofdiseases.Weareseeingdramaticincreasesinchronicdiseases,andatyoungerages,manyofwhich,suchasdia
4、betes,arethemselvesriskfactorsfordementia.Theover-65populationwillnearlydoubleby2030tomorethan71million,sharplyincreasingthenumberofpeopleatriskofchronicdiseasesofaginglikeAlzheimer’sandParkinson’sdiseases,amongothers.Environmentalfactorsplayakeyroleinhealthacrossthelifespan.Thustheyof
5、feramajorpreventionopportunity.TheChangingEnvironmentand DiseasePatternsDuringthepastcentury,humanactivityhasalteredvirtuallyallaspectsoftheworld’secosystems:Pervasivespreadofsyntheticchemicals;airandwaterpollution.Industrializedfoodsupply.Destructionofcriticalnaturalhabitats,stressing
6、ecosystems.Climatechange.Howwelive,eat,work,playandsocializehavesubstantiallychanged:Builtenvironmentshaveincreasedsocialisolationformanypeople;reducedphysicalactivity.Growingincomegapincreasesdiseaserisk.Diseasesofcivilization-obesity,diabetes,cardiovasculardisease,hypertension.Enviro
7、nmentDrivesChronicDiseaseWesternDiseaseClusterDiabetesObesityAbnormalLipidsMetabolicSyndromeCardiovascularDiseaseFoodsystem/DietFossilFuelsSocioeconomicStressChemicalsBuiltEnvironment/TransportationInflammationDisruptedInsulinSignalingOxidativeStressAlzheimer’sParkinson’sAlteredPathw
