含奥沙利铂的新辅助动脉灌注化疗治疗进展期胃癌的临床观察

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1、含奥沙利钴的新辅助动脉灌注化疗治疗进展期胃癌的临床观察刘红杨会利刘蔚莎郭春辉高玉凯（山东滨州市屮心医院251700）【摘要】目的为研究新辅助介入化疗治疗进展期H癌的术后病理变化及临床疗效。方法对50例进展期胃癌随机分为两组，研宂组25例行含奥沙利铂的动脉灌注化疗；对照组25例行全身静脉化疗。前者采用seldinger技术，根据癌灶部位选择相应的动脉插管，化疗方案选择奥沙利铂85mg/m2,替加氟1000mg/m2、阿霉素25mg/m2o两周期后7-10大手术治疗；后者25例患者*选择奥沙利铀85mg/m2dl，亚叶酸弼20

2、0mg/m2dl-2,氟尿卩密陡400mg/m2ivdl-2,氟尿嘧啶600mg/m2CIVdl-2。两周期全身化疗后10-14天手术治疗，对术后胃癌标本进行组织病理学检查及术后2年生存率。结果两组术后组织病理学改变总有效率分别55.6%,36.52%。两组比较有统计学差异（P<0.05）。2年生存率分别为70%和54.2%两组比较有统计学差异（P<0.05）。结论术前含奥沙利铂的新辅助介入化疗对进展期胃癌是一种安全有效、切实可行的辅助治疗方法，并发症少于全身化疗，对手术切除率和生存率有提高，有待大祥本的研究。【关键词】动

3、脉灌注化疗进展期胃癌生存率【中图分类号】R730.5【文献标识码】A【文章编号】1672-5085（2014）14-0050-02ClinicalobservationontheeffectofneoadjuvantintraarterialchemotherapyinthetreatmentofadvancedgastriccancerwithoxaliplatinLiuHongYangHuiliLiuWeishaGuoChunhuiGaoYukai,BinzhouCentralHospital,Shandong2517

4、00【Abstract】ObjectiveTostudyofneoadjuvantchemotherapyforadvancedgastriccancerpostoperativepathologicalchangesandclinicaleffect.Methods:50casesofadvancedgastriccancerwererandomlydividedintotwogroups,thestudygroupof25casesofarterialinfusionchemotherapywithoxaliplati

5、n;thecontrolgroupof25casesofsystemicvenouschemotherapy.TheformerusesSeldingertechnology,accordingtolesionlocationselectivearterialcorresponding,oxaliplatin85mg/m2chemotherapyregimentegafur,doxorubicin,1000mg/m225mg/m2.Thetwocycle7-10daysafteroperationtreatment;the

6、latter25patientsselected85mg/m2DIoxaliplatin,calciumfolinate200mg/m2Dl-2,fluorouracil400mg/m2ivdl-2,600mg/m2CIVdl-2fluorouracil.Thetwocycleofchemotherapytreatment10-14daysafteroperation,thepostoperativegastriccancerspecimensforexaminationandsurgerypathologyafter2y

7、earsurvivalrate.Results:thetwogroupsofpostoperativepathologychangeandtotaleffectiveratewere55.6%,36.52%.Asignificantdifferencebetweentwogroups(P<0.05).The2yearsurvivalrateswere70%and54.2%,asignificantdifferencebetweentwogroups(P<0.05).Conclusion:neoadjuvantp

8、reoperativeinterventionalchemotherapycontainingoxaliplatinisasafe,effective,feasibletreatmentmethodforadvancedgastriccancer,complicationslessthansystemi