mpo水平对pci治疗患者住院期间主要不良心血管事件预测价值

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1、MPO水平对PCI治疗患者住院期间主要不良心血管事件预测价值【摘要】目的探讨髓过氧化物酶(MPO)在急性心肌梗死患者(AMI)经皮冠状动脉介入治疗(PCI)后的动态变化及对患者不良心血管事件(MACE)发生的预测价值。方法选取本院心血管内科2013年1月〜2015年1月釆用PCI治疗的127例AMI患者进行回顾性分析，根据患者术后是否发生不良心血管事件(MACE)分为MACE组43例、非MACE组84例，对比两组患者手术前后的血清MPO水平变化趋势，并采用受试者工作曲线(ROC)分析MPO预测MACE的最佳临界值。结果MACE组和非MACE组患者的血Scr、TC、TG、HDL-C

2、、LDL-C、SBP、DBP水平比较差异均无统计学意义(p>0.05)；MACE组患者术前、术后30min、术后4h、术后12h、术后24h的外周血MPO水平均显著的高于非MACE组患者(P〈0.05);在MPO取值794ng/ml时有最大的诊断指数1.683,此时对应的曲线下面积AUC值为0.841，、灵敏度为86.32%、特异度为81.98%。结论AMI患者PCI治疗后并发MACE患者的MPO水平会显著的升高，PCI术后4h的MPO水平预测患者并发MACE具有一定的临床价值。【关键词】髓过氧化物酶；急性心肌梗死；皮冠状动脉治疗；不良心血管事件PredictiveValueof

3、majoradversecardiovasculareventsduringtheMPOlevelsonPCIpatientshospitalized［AbstractlObjectiveToinvestigatethemyeloperoxidase(MPO)inpatientswithacutemyocardialinfarction(AMI)afterpercutaneouscoronaryintervention(PCI)andthedynamicchangeofpatientswithadversecardiovascularevents(MACE)occurrencep

4、redictionvalue.MethodsSelectcardiovascularmedicinehospitalinJanuary2013January2015wereretrospectivelyanalyzed127casesofAMIpatientstreatedwithPCI,dependingonwhetherpostoperativeadversecardiacevents(MACE)occurrenceofMACEgroupisdividedinto43casesofnon-MACE84patients,serumlevelsofMPOtrendscontras

5、ttwogroupsofpatientsbeforeandaftersurgery,andtheuseofreceiveroperatingcurve(ROC)analysisofMPOpredicttheoptimalthresholdofMACE.ResultsMACEMACEgroupandnon-groupofpatientswithbloodScr,TC,TG,IIDL-C,LDL-C,SBP,DBPleveldifferencewasnotstatisticallysignificant(P>0.05);preoperativeMACEgroup,after30min

6、，after4h，after12h,24hafterperipheralbloodMPOlevelsweresignificantlyhigherthannon-MACEpatients(P<0.05);whentheMPOvalues794ng/nilhasthegreatestdiagnosticindexof1.683,thenthecorrespondingareaunderthecurveAUCvalueof0.841，，sensitivityof86.32%andaspecificityof81.98%.ConclusionWillthelevelofMPOinpat

7、ientswithMACEaftertreatmentwithAMIPCIsignificantlyincreased,4HlevelofMPOPCIinpredictingpostoperativepatientswithMACEhascertainclinicalvalue.［Keywords］Myeloperoxidase;acutemyocardialinfarction;percutaneouscoronaryintervention;adversecardiovasc