欢迎来到天天文库
浏览记录
ID:20858188
大小:2.15 MB
页数:24页
时间:2018-10-17
《血浆醛固酮2f肾素活性比值在原发性醛固酮增多症筛查诊断中的临床应用》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、大连医科大学硕士学位论文ClinicalsignificanceofaldosteronetoreninratioinscreeningprimaryaldosteronismMasterdegreecandidate:BaishuangZhangSupervisor:ProfessorYanLuVice—supervisor:ProfessorYinongJiangMajor:InternalMedicineAbstractObjective:Inrecentyears,theassessment
2、oftheplasmaaldostemne—to-reninratio(ARR)hasbecomeaeveryeffectiveandwidelyusedmethodforscreeningprimaryaldosteronismfromhypertensives.ItiswellknownthatthereisalargevarianceinARRvaluebetweendifferentracesandregion,MeanwhileARRCanbeaffectedbymanyfactors,s
3、uchasdrugs,postureanddetectiontimeetc.Thereceiveroperatingcharacteristic(ROC)curvewasusedtoevaluatethevalueofaldosteronetoreninratio(ARR)inscreeningprimaryaldosteronism.Methods:TheclinicaldataofARRinsupineanduprightpositionswerecollectedfrom301patients
4、whoissuspectedhasprimaryaldosteronismduringMarch2012toSeptember2013.supineanduprightARRdetectionandSalineinfusiontestwereperformedforalltheparticipants.105patientswerediagnosedprimaryaldosteronismand196patientswereessentialhypertensionamongallparticipa
5、nts.Gender,age,thecourseofhypertension,BMI,systolicbloodpressure,diastolicbloodpressure,serumsodium,potassium,urinarysodium,urinarypotassium,supinePRA,uprightPRA,supinePAC,uprightclinicaldataPAC,supineARR,uprightARRwerecollectedforstatisticalanalysis.A
6、tlastusetheROCcurvetodefinethebestcut-offvalueofARRforscreeningprimaryaldosteronismfromhypertensives.Results:IntheanalysisoftheclinicaldataofPAgroupandEHgroup,Wefindtheiteamsofsupine/uprightPAC,ARRlevelsinEHgroupwerelowerthanthatofPAgroup,andthesupine/
7、uprightplasmaPRAWashigherthanthatofPAgroup,thedifferencebothhavestatisticalsignificance((P<0.05);theareaundertheROCcurveofsupineARRis0.7633大连医科大学硕士学位论文(0.717—0.813),theareaundertheROCcurveofuprightARRis0.909(0.868—0.941),therewassignificantlydifference
8、betweenthesetwoareasundertheROCcurve(P<0.01);theareaundertheROCcurveofuprightPRAisO.814(0.762—0.859),theareaundertheROCcurveofuprightPACisO.684(0.625-0.074),therewassignificantlydifferencebetweenthesetwoareasundertheROCcurve(P
此文档下载收益归作者所有