microrna在flt3-itd突变急性髓系白血病中的作用机制研究进展

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1、授予单位代码10089学号或申请号20153159中国图书分类号R733.71HebeiMedicalUniversity硕士学位论文专业学位MicroRNA在FLT3-ITD突变急性髓系白血病中的作用机制研究进展研究生：杨帆导师：罗建民教授专业：内科学二级学院：河北医科大学第二医院2018年3月目录中文摘要············································································································1英文摘要········

2、····································································································2英文缩写············································································································3综述MicroRNA在FLT3-ITD突变急性髓系白血病中的作用机制研究进展························

3、····················································································4致谢··················································································································25个人简历·····································································

4、·····································26中文摘要MicroRNA在FLT3-ITD突变急性髓系白血病中的作用机制研究进展摘要FMS样酪氨酸激酶3(FLT3)受体的内部串联重复(ITD)突变是急性髓系白血病中较常见的一种突变类型，其特点有外周血白细胞计数较高、骨髓象中原始及幼稚细胞比例高、诱导缓解率低、复发频次高、长期生存时间短、预后较差等。由于多种原因，目前FLT3酪氨酸激酶抑制剂(TKI)的疗效并不满意，而且，造血干细胞移植效果也不理想。近年来，对于microRNA的研究突飞猛进，在FLT3-ITD突变阳性

5、急性髓系白血病治疗策略上，microRNA将会是一个很具有吸引力的突破点，本文总结microRNA在FLT3-ITD突变阳性急性髓系白血病中的研究进展，探讨microRNA在急性白血病的病因、诊断及预后方面的重要的价值。关键词：微小RNA，FLT3-ITD，急性髓系白血病，突变，治疗1英文摘要ProgressinthemechanismofactionofMicroRNAinFLT3-ITDmutationinacutemyeloidleukemia.ABSTRACTFMS-liketyrosinekinase3(FLT3)receptorint

6、ernaltandemduplication(ITD)mutationisacommontypesmutationofacutemyeloidleukemia,ithasthecharacteristicsincludinghighercountperipheralwhitebloodcell,highrateofbonemarrowprimitiveandimmaturecells,lowinducedrelievingrate，highrecurrencerate,poorprognosisandlong-termsurvivalshort.

7、Formanyreasons,thetreatmenteffectofFLT3tyrosinekinaseinhibitor(TKI)isnotsatisfactory,andtheeffectofhematopoieticstemcelltransplantationissatisfactoryeither.Inrecentyears,theresearchofmicroRNAisdevelopingrapidly.MicroRNAwillbeanattractivebreakthroughinthetreatmentstrategyofFLT

8、3-ITDmutationpositiveacutemyeloidleukemia.Inthisarticle,wesummarized