资源描述：
《LIPID研究PPT课件.ppt》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。
1、TheLong-TermInterventionwithPravastatininIschemicDisease (LIPID)TheLIPIDStudyGroupNEnglJMed1998;339:1349-57LIPID-BackgroundInpatientswithCHDandabroadrangeofcholesterollevels,cholesterol-loweringtherapyreducestheriskofCVevents,buttheeffectsonCVmortalityandove
2、rallmortalityhaveremaineduncertain.NEnglJMed1998;339:1349-57LIPID-StudyDesignDouble-blind,randomized,placebo-controlledtrial.40mgpravastatinvs.placebo9,014menandwomen,31to75yearsofage,at87centersinAustraliaandNewZealand.PatientswereeligibleiftheyhadhadanMIor
3、unstableangina(requiringhospitalization)between3and36monthsbeforestudyentry.BaselineTC155-271mg/dL,TG<445mg/dLNEnglJMed1998;339:1349-57LIPID-EndpointsPrimaryendpoint:deathfromCHDSecondaryendpoints:deathfromanycause;deathfromcardiovascularcauses;deathfromCHDo
4、rnonfatalMI;MI;stroke;nonhemorrhagicstroke;coronaryrevascularization;numberofdaysinthehospital;serumlipidlevels;andtherelationofchangesinlipidlevelstotheoccurrenceofcardiovascularendpoints.NEnglJMed1998;339:1349-57LIPID-BaselineCharacteristicsCharacteristicP
5、laceboPravastatin(n=4502)(n=4512)Age<55yr,no.(%)1021(23)1065(24)55-64yr,no(%)1708(38)1706(38)65-69yr,no(%)1087(24)1081(24)>70yr,no(%)686(15)660(15)Median,yr6262Sex,no(%)Male3742(83)3756(83)Female760(17)756(17)NEnglJMed1998;339:1349-57LIPID-BaselineCharacteri
6、sticsCharacteristicPlaceboPravastatin(n=4502)(n=4512)Qualifyingevent,no(%)Myocardialinfarction2875(64)2879(64)Unstableangina1627(36)1633(36)Coronaryriskfactors,%Currentsmoker109Formersmoker6365Hypertension4241Antihypertensivetreatment3836Diabetesmellitus99Ob
7、esity1818NEnglJMed1998;339:1349-57LIPID-BaselineLipidLevelsPlaceboPravastatin(n=4502)(n=4512)LipidLevels,mg/dLTotalcholesterol,median218218LDLcholesterol,median150150HDLcholesterol,median3636Triglycerides,median138142Total:HDLratio6.076.11NEnglJMed1998;339:1
8、349-57LIPID-LipidLevelChangesWith40mgPravastatinOver5YearsofFollow-upP<0.001forallcomparisonsvs.placeboNEnglJMed1998;339:1349-57LIPID-CardiovascularEventsAccordingtoTreatmentGroupEventPlaceboPra
