阿托伐他汀对糖尿病大鼠肾脏sirt1表达的影响及其可能的肾脏保护作用

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1、授予单位代码10089学号或申请号20152094中国图书分类号R587.2HebeiMedicalUniversity硕士学位论文学术学位阿托伐他汀对糖尿病大鼠肾脏SIRT1表达的影响及其可能的肾脏保护作用研究生：韩丹丹导师：赵占胜教授专业：内科学二级学院：河北医科大学第二医院2018年3月目录中文摘要····································································································10英文摘要·····················

2、·········································································40英文缩写··························································································80研究论文阿托伐他汀对糖尿病大鼠肾脏SIRT1表达的影响及其可能的肾脏保护作用前言·····································································

3、······················10材料与方法··················································································11结果···························································································21附图······································································

4、·····················23附表··························································································29讨论·····························································································31结论································································

5、·····························34参考文献·······················································································34综述Sirt1的研究现状·······································································38致谢·····································································

6、························49个人简历··························································································50中文摘要阿托伐他汀对糖尿病大鼠肾脏SIRTl表达的影响及其可能的肾脏保护作用摘要目的：随着糖尿病发病率的逐渐升高，人们对糖尿病的并发症越来越重视。糖尿病肾病是糖尿病的严重微血管并发症，作为终末期肾病的主要原因之一，致死致残率高，给糖尿病患者和社会带来极大的危害[1]。研究发现，糖尿病肾病的发生与氧化应激、炎症反应、

7、能量代谢、肾素血管紧张素、遗传等因素的综合作用有关[2]。SIRT1即沉默接合型信息调节因子2同源蛋白1(silentmatingtypeinformationregulation2homolog1，Sirtuin1)，是Sir家族7种中去乙酰化酶中研究最多的一种酶,它是哺乳动物中与酵母沉默信息调节蛋2(silencinginformationregulator2，Sir2)高度同源的一种蛋白质，是依赖烟酰胺腺嘌呤二核苷酸（NAD+)组蛋白的一种去乙酰化酶，研究认为，SIRTl在神经退行性变，代谢性疾病，心血管病，肿瘤以及与衰老相关性疾病的病理过程、疾病

8、进展、治疗过程中具有非常的重要作用[3]。ChuangPY等认为SIRT1的活化