抗栓联合抗炎疗法治疗急性脑梗死患者的临床疗效评价及安全性研究

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1、授予单位代码10089学号或申请号15145中国图书分类号R743.3HebeiMedicalUniversity硕士学位论文学术学位抗栓联合抗炎疗法治疗急性脑梗死患者的临床疗效评价及安全性研究研究生：刘荣导师：檀国军教授专业：神经病学二级学院：河北医科大学第二医院2018年3月目录中文摘要·········································································································

2、·1英文摘要··········································································································2研究论文抗栓联合抗炎疗法治疗急性脑梗死患者的临床疗效评价及安全性研究前言······································································································

3、····4资料与方法······························································································5结果··········································································································7附表···································

4、·······································································8讨论··········································································································9结论····································································

5、······································15参考文献··································································································15附录·········································································································

6、·18综述急性脑梗塞的免疫相关机制进展·····················································22致谢···············································································································37个人简历··························································

7、··············································38抗栓联合抗炎疗法治疗急性脑梗死患者的临床疗效评价及安全性研究摘要目的：探索抗栓基础上联合小剂量地塞米松的抗炎疗法治疗急性脑梗死患者的临床效果及安全性。方法：将24小时内发病的40例急性脑梗死患者随机分为小量地塞米松组、微小剂量组、微量地塞米松组及对照组。在常规抗栓和他汀治疗（对照组）的基础上分别加用地塞米松1.25mg、2.5mg、5mg（依次为微量地塞米松组、微小量地塞米松组、小量地塞米松组）静脉滴注

8、，每天一次，共7d。各组分别于治疗后的第1天、7天行血常规及血沉检查，于治疗后的第1个月和第3个月采用Barthel指数及Rankin量表对所有脑梗死患者进行神经系统的功能评定。结果：小量组的血沉较微小剂量组、微量组及对照组明显减慢，且差异有显著性（P<0.05），而微小剂量组与微量组及对照组无明显差异。根据Barthel指数及改良的Rankin量表评定结果，小量组的神经功能较微小剂量组、微量组及对照组明显改善，且差异有显著性（P<0.05），而微小剂量组与微量组及对照组无明显差异