抑制剂在心血管疾病中的应用ppt课件

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1、UseofAnalgesicsMostcommonlyusedmedicationsintheUSbysurveydata#1:acetaminophen#2:ibuprofen#3:aspirin–50%ofusersonforcardiovascularprophylaxisAmongmostfrequentlyprescribedmedstothoseover65OTCanalgesicuseunderreportedtohealthcareprovidersand10-40%ofthoseprescribedNSAIDsconcomitantlyuseOTCNSAIDsKau

2、fman,JAMA2002;287:337-344Hensrud,MayoClinProc1999;74:443-447Eliason,JAmBoardFP1996;9:249-253队甚咱食串讹诵更零洲榴庙寒擦霜哩祭丰腕题帽熄眉挨录舀焙壕差乳瓶蘑cox-2抑制剂在心血管疾病中的应用ppt课件cox-2抑制剂在心血管疾病中的应用ppt课件UseofAnalgesicsEachyearintheUS:Over30billionOTCNSAIDtabletssold(~$2billion)Over70millionNSAIDprescriptionswrittenNSAIDshavebe

3、enpotentiallyimplicatedin~16,500deathsand~100,000hospitalizationsforadverseevents;mostareduetoGIbleedsorrenalimpairmentTheseadmitscostthehealthcaresystem~$2billion.TreatmentofNSAID-relatedgastrointestinalsideeffectsaccountsforonethirdofthecostofarthritistherapyEventhoughadvancedageiswell-knownf

4、actorforadverseGIandrenalevents,overhalfofpatientsover65havebeenprescribedNSAIDs.Wolfe,NEJM1999;340:1888-1899Curhan,ArchInternMed2002;162:2204-2208Tamblyn,AnnInternMed1997;127:429-438栓帕家拐坠犯才键耽优鼓菠掺甚胡诞砷咳芜跳苯崇尝哼妮稍镰峡跋簧恿激cox-2抑制剂在心血管疾病中的应用ppt课件cox-2抑制剂在心血管疾病中的应用ppt课件Useofnon-aspirinNSAIDsinconjunctio

5、nwithaspirinforprimaryprophylaxismayincreasetheriskoffirstMI22,000malephysiciansonaspirin325mgQODorplaceboAspirinusewasassociatedwitha44%relativeriskreductionoffirstMIConcomitantNSAIDusefor60days/yrassociatedwithincreasedriskoffirstMI(RR2.86;95%CI1.25-6.56)Kurth,Circulation2003;108:1191-1195Po

6、ssibleAdverseInteractionsbetweenNSAIDsandASA:Physician’sHealthStudy丹然磅肝机进唤榨甥扣阶萄拽亢考扁哎圈傈售廉何像变哦嚣轴讨缉圾涅础cox-2抑制剂在心血管疾病中的应用ppt课件cox-2抑制剂在心血管疾病中的应用ppt课件PossibleAdverseInteractionsbetweenNSAIDsandASAUseofNSAIDSinconjunctionwithASAinpatientsafter1stCVadmission(angina,MI,CVA,TIA,PVD)7,107patientsAdminis

7、trationofibuprofenwithaspirinwasassociatedwithanincreasedriskofall-causemortality(adjustedHR1.93,95%CI1.30-2.87,p=0.001)andCVmortality(1.73,1.05-2.84,p=0.031)comparedtoadministrationofASAaloneSimilarriskswerefoundamongpatientsinAS