多发性硬化英文 ppt课件

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1、MultipleSclerosisandCurrentlyAvailableTreatmentsintheUSMichelleRainka,Pharm.D.,CCRPDentInstituteUniversityatBuffalomrainka@dentinstitute.commmrainka@buffalo.eduCopyright©:Reproductionoftheseslidesisprohibitedwithoutpermissionoftheauthor“Multiple”-multipleareasoflostmyelin“Sclerosis”-Scarri

2、ngMSisachronicautoimmuneinflammatorydiseaseAffectsCentralNervousSystem(brain,spinalchordandopticnerves)MultipleSclerosisInternationalJournalofMSCareMultipleSclerosisMultipleSclerosisAchronic,autoimmunediseaseAffectscentralnervoussystemthemyelinsheathcoveringofnervefibersinthebrainandspina

3、lcordImpairsthenervesabilitytosendelectricalimpulsesMSStatisticsApproximately400,000AmericansarediagnosedwithMSAffects2.5millionpeopleworldwideSymptomonsetanddiagnosisoccurtypicallybetweentheagesof20-502.5:1women:manratioPeopleofNorthernEuropeandescentareafflictedmostcommonlyMorecommonabov

4、e40°latitudeinareaslikewesternNewYork.Womenare2timesmorelikelytogetthedisease(i.e.2womenforevery1men)MorecommoninNorthernEuropeandescendantsthananyotherraceFoundinpeoplewholiveintemperateclimatesOnsetoccursbetweenagesof20and40http://multiplesclerosis.net/what-is-ms/statistics/SymptomsofMSM

5、uscleweaknessVisualsymptomsBlurryvisionDoublevisionUnsteadygait/balanceissuesPain/ParesthesiasEmotional/CognitivedisturbancesShorttermmemorylossInabilitytoconcentrateFatigueSexualDysfunctionSpeechSwallowingAbnormalsensationsTinglingNumbnessSensitivitytoheatBladderandbowelproblemsFrequencyL

6、ossofcontrolMultipleSclerosisKurtzkedisabilitystatusscale1Nodisability&minimalneurologicsign2Minimaldisability-slightweaknessorstiffness,milddisturbanceofgaitormildvisualdisturbance3Moderatedisability-monoparesis(partialorincompleteparalysisaffectingoneorpartofoneextremity)mildhemiparesis(

7、slightparalysisaffectingonesideofbody)moderateataxia,disturbingsensoryloss,prominenturinaryoreyesymptom,oracombinationoflesserdysfunction4Relativelyseveredisability,butfullyambulatorywithoutaid,selfsufficientandabletobeupandabout12hoursaday,doesnotpreventtheab