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1、持续正压通气治疗对29例OSAHS患者血脂、血糖的影响分析甘玉燕张文刘学锋王陈金(福建医科大附属宁德市医院福建宁德352100)【摘要】A的：探讨重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者持续正压通气治疗前后血脂和空腹血糖(FBG)的变化。方法：29例成年重度OSAHS患者经CPAP治疗前及治疗后(4周、24周)测体重、血脂水平、FBG等各项指标,并进行统计学分析。结果：OSAHS患者经Auto-CPAP治疗后血淸总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-CH)、FBG呈现下降趋势，而高密度脂蛋白(HDL-CH＞出现升高趋势，这种升高和K
2、降的趋势在治疗24周后差异有统计学意义(P<0.05),但在治疗4周前血脂、血糖水平变化差异无统计学意义(P>0.05＞。经24周治疗后体重指数(BMI)明显下降，从治疗前(30.2±3.2}kg/m2下降至lJ(27.8±6.3)kg/m2(P<0.05)。结论：使用CPAP治疗24周后可以改善重度OSAHS患者的BMI、血脂、血糖;减轻体重以及纠正睡眠呼吸紊乱在改善OSAHS患者的糖脂代谢异常方面有着重要意义。【关键词】睡眠呼吸暂停低通气综合征;阻塞性；血脂;血糖;持续正压通气【屮图分类号】R45【文献标识码】A【
3、文章编号】2095-1752(2015)06-0018-02AnalysisofContinuouspositiveairwaypressuretreatmentin29patientswithOSAHSofbloodlipidandbloodsugarimpactGanYuyan,ZhangWen,LiuXuefeng,WangChenjin.FujianMedicalUniversityAffiliatedNingdeHospital,Ningde352100,China【Abstract】ObjectiveStudyofsevereobstructivesl
4、eepapneahypopneasyndrom(OSAHS)patientsbeforeandaftertreatmentofcontinuouspositiveairwaypressurechangesofbloodlipidandfastingbloodglucose(FBG).Methods29casesofadultpatientswithsevereOSASCPAPtreatmentbeforeandaftertreatment(4weeksand24weeks)tomeasureweight,lipidlevels,FBG,suchastheindic
5、ators,andstatisticalanalysis.ResultsOSAHSpatientsaftertreatmentwithAuto-CPAPserumtotalcholesterol(TC),triglycerides(TG),lowdensitylipoprotein(LDL-CH)presentsdowntrend,FBG,andhigh-densitylipoprotein(HDL-CH)appearedrisingtrend,thetrendoftheriseandfallofthe24weeksaftertreatmentwasstatist
6、icallysignificantdifference(P<0.05),24weeksafterthetreatmentofbodymassindex(BMI)significantlydecreased,frombeforethetreatment(30.2+/-3.2)kg/m2droppedto(27.8+/-6.3)kg/m2(P<0.05).ConclusionsUsingCPAPtreatmentcanimprovethesevereOSAHSpatientsafter24weeksofBMI,bloodlipid,bloodsugar;W
7、eightlossandcorrectsleep-relatedbreathingdisorderinimprovingtheglucolipidmetabolicabnormalitiesinpatientswithOSAHShasimportantsignificance.【Keywords】Sleepapnea;SyndromObstructive;Bloodlipid;Bloodsugar;Continuouspositiveairwaypressure阻塞性睡眠呼吸暂停低通气综合征(OSAHS)常伴冇糖脂代谢紊乱，被认为是一种代谢综合征，其糖脂代谢紊乱与
8、呼吸暂停、
