磁敏感加权成像对帕金森病患者病情评估的价值

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1、授予单位代码10089学号或申请号20153354中国图书分类号R742.5HebeiMedicalUniversity硕士学位论文专业学位磁敏感加权成像对帕金森病患者病情评估的价值研究生：郭晓云导师：刘俊艳教授专业：神经病学二级学院：第三医院2018年3月目录中文摘要·················································································1英文摘要·······································································

2、··········3英文缩写·················································································5研究论文磁敏感加权成像对帕金森病患者病情评估的价值················前言·················································································6材料与方法·································································

3、·······6结果·················································································7附图·················································································9附表···············································································10讨论·······························

4、················································11结论···············································································13参考文献·········································································13综述核磁共振3DSPACE神经成像技术与周围神经病的诊断··········17致谢······································

5、···············································29个人简历···············································································30中文摘要磁敏感加权成像对帕金森病患者病情评估的价值摘要目的：探讨磁敏感加权成像（SusceptibilityWeightedImaging，SWI）对帕金森氏病（Parkinson’sDisease,PD）患者病情评估的价值。方法：收集2015年6月至2018年2月在河北医科大学第三医院神经内科明确诊断为PD患者4

6、5例，病程0.5~20年，UPDRSⅢ评分为（39±8）分，H&Y(Hoehn&Yahr)分期：2期以下3例；2期至4期以下36例；4期及以上6例；平均（3±1）期。选取年龄、性别相匹配的非锥体外系疾病的患者30例作为对照。所有被研究者均接受头颅SWI检查，评估PD患者黑质、红核、苍白球、壳核及尾状核等感兴趣区(regionofinterest,ROI)SWI所示信号强度值，分析各ROI信号强度值与UPDRSⅢ和H&Y分期的相关性。结果：与对照组患者相比，PD组患者黑质、红核及壳核信号强度值明显降低，差异有统计学意义（黑质：t值=-2.750P=0.014；红核：t值=-2.9

7、80P=0.004；壳核：t值=-2.112P=0.038）；而苍白球和尾状核信号强度值无明显降低，差异不具有统计学意义（苍白球：t值=-1.420P=0.160；尾状核：t值=-1.64P=0.104）。Pearson相关分析表明：PD患者UPDRSⅢ评分与黑质和壳核信号强度值呈负相关（黑质：r值=-0.362P=0.015；壳核：r值=-0.296P=0.048），而与红核、苍白球及尾状核无相关性（红核：r值=-0.262P=0.082；苍白球：r值=-0.225P=0.138；尾状核：