血清1%2c25-二羟维生素d3水平与类风湿关节炎的关系

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1、授予单位代码10089学号或申请号16010中国图书分类号R593.2HebeiMedicalUniversity硕士学位论文学术学位血清1,25-二羟维生素D3水平与类风湿关节炎的关系研究生：宋丽丽导师：彭晨星副教授专业：内科学二级学院：第二医院2018年3月目录中文摘要··········································································································1英文摘要······················

2、····················································································3英文缩写··········································································································6研究论文血清1,25-二羟维生素D3水平与类风湿关节炎的关系前言··········································

3、································································7材料与方法··········································································································13结果··························································································

4、················19附图··········································································································21附表··········································································································22讨论······························

5、············································································24结论··········································································································32参考文献··············································································

6、····························32综述维生素D对类风湿关节炎免疫调节作用研究进展···················37致谢··········································································································47个人简历··················································································

7、························48血清1,25-二羟维生素D3水平与类风湿关节炎的关系摘要类风湿关节炎（rheumatoidarthritis,RA）是常见的自身免疫性疾病，主要的临床特点是对称性、进行性和侵蚀性的关节炎，具有较高的致残率和死亡率，患病率占世界总人口的0.5%~1.0%，其发病机制尚未阐明。近年有研究显示其发病机制可能与免疫平衡破坏有关。维生素D（VitaminD，VitD）是脂溶性固醇类衍生物，目前发现其生物学作用越来越多，已经超过传统范围，涉及肿瘤、内分泌、免疫等方面。越来越多研究发现，VitD与

8、多种自身免疫疾病相关，如系统性红斑狼疮（systemiclupuserythematosus,SLE）、RA等，在免疫系统中发挥重要的调节作用。RA患者经常伴有VitD缺乏，与疾病的病情活动和严重程度相关，且VitD还能